855420-54-1Relevant academic research and scientific papers
Ambient temperature synthesis of spiro[indoline-3,2′-thiazolidinones] by a DBSA-catalyzed sequential reaction in water
Preetam, Amreeta,Nath, Mahendra
, p. 1502 - 1506 (2016)
An energy-efficient eco-friendly methodology for the synthesis of a series of pharmacologically important spiro[indoline-3,2′-thiazolidinones] has been developed by the reaction of primary amines with various isatin derivatives and thioglycolic acid in the presence of p-dodecylbenzenesulfonic acid (DBSA) as an efficient Br?nsted acid surfactant combined catalyst in aqueous medium at 25 °C. This synthetic protocol demonstrates several advantages such as operational simplicity, energy-efficiency, good to excellent isolated yields, and the use of a preferred green solvent system for the preparation of desired products.
Synthesis and X-ray study of dispiro 8-nitroquinolone analogues and their cytotoxic properties against human cervical cancer HeLa cells
Shyamsivappan, Selvaraj,Vivek, Raju,Saravanan, Arjunan,Arasakumar, Thangaraj,Subashini, Gopalan,Suresh, Thangaraj,Shankar, Ramasamy,Mohan, Palathurai Subramaniam
supporting information, p. 439 - 449 (2019/03/28)
A series of unique dispiro analogues containing an oxindole pyrrolidine 8-nitroquinolone hybrid has been obtained through a one-pot three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the condensation of isatins and benzylamine with (E)-3-arylidene-2,3-dihydro-8-nitro-4-quinolones. The structures of the newly synthesized compounds were characterized by using different spectroscopic techniques and by X-ray diffraction studies of their regio- and stereochemistry. All the synthesized compounds were screened for in vitro cytotoxic activity against the human cervical cancer cell line HeLa. The compounds have exhibited potent inhibition against human cervical cancer cells and insignificant toxicity to normal cells. The compounds 6d, 6a, 6h, 6b, and 6e induced apoptosis of HeLa cells, through ROS influx. The expression levels of proteins involved in the mitochondrion-related pathways were detected, and Western blot analysis showed that apoptosis occurred via activation of caspase-3.
Microwave-Assisted, Solvent-Free Synthesis of 3′-(Aryl/Heteroaryl)-1- morpholinomethyl/piperidinomethylspiro[3H- Indole-3,2′-thiazolidine]-2, 4′(1H)-diones via 3-Isatinimines
Pandey, Manju,Raghuvanshi, Dushyant Singh,Singh, Krishna Nand
experimental part, p. 49 - 53 (2009/06/18)
The solvent-free, microwave (MW)-assisted synthesis of a new series of 3′-(aryl/heteroaryl)-1-mor-pholinomethyl/piperidinomethylspiro[3H-indole- 3,2′-thiazolidine]-2,4′(1H)-diones has been achieved in an open vessel. Isatins 1 undergo an easy condensation
