855423-23-3Relevant academic research and scientific papers
Optical Manipulation of F-Actin with Photoswitchable Small Molecules
Borowiak, Malgorzata,Küllmer, Florian,Gegenfurtner, Florian,Peil, Sebastian,Nasufovic, Veselin,Zahler, Stefan,Thorn-Seshold, Oliver,Trauner, Dirk,Arndt, Hans-Dieter
, p. 9240 - 9249 (2020)
Cell-permeable photoswitchable small molecules, termed optojasps, are introduced to optically control the dynamics of the actin cytoskeleton and cellular functions that depend on it. These light-dependent effectors were designed from the F-actin-stabilizing marine depsipeptide jasplakinolide by functionalizing them with azobenzene photoswitches. As demonstrated, optojasps can be employed to control cell viability, cell motility, and cytoskeletal signaling with the high spatial and temporal resolution that light affords. Optojasps can be expected to find applications in diverse areas of cell biological research. They may also provide a template for photopharmacology targeting the ubiquitous actin cytoskeleton with precision control in the micrometer range.
AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS
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Page/Page column 103, (2015/11/23)
The invention concerns a new class of tubulin polymerisation inhibitors and their applications in research and medicine, notably in chemotherapy. The invention proposes new azoaryl derivatives of formula (I): as defined in Claim 1, which may be fully reve
Synthesis, mesomorphism and dielectric behaviour of novel basket shaped scaffolds constructed on lower rim azocalix[4]arenes
Sutariya, Pinkesh G.,Modi, Nishith R.,Pandya, Alok,Rana,Menon, Shobhana K.
, p. 4176 - 4180 (2013/05/09)
A newly designed series of lower rim azocalix[4]arene basket type mesogens were synthesised and fully characterized. The proposed supramolecular organization displays needle shaped, rod like, focal conic and schlieren textures. These compounds were studied for their dielectric properties in the frequency range 100 Hz-2 MHz at variable temperatures (50-110 °C). The Royal Society of Chemistry 2013.
