855429-61-7

Upstream product

• 30516-87-1 3'-azido-2',3'-deoxythymidine 
• 312750-63-3 O-(N^α-tert-butoxycarbonyl-L-tert-butoxytyrosinyl) O-(S-pivaloyl-2-thioethyl) N,N-diisopropylphosphoramidite 
• 3978-80-1 Boc-Tyr-OH 
• 18938-60-8 (S)-tert-butyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanoate 
• 200502-01-8 S-pivaloyl-2-thioethyl di(N,N-diisopropylamino)phosphoramidite 
• 153121-88-1 S-(2-hydroxyethyl) 2,2-dimethylpropanethioate 

Downstream Products

• 312750-67-7 O-(N^α-tert-butoxycarbonyl-L-tert-butoxytyrosinyl) O-(S-pivaloyl-2-thioethyl) 3'-azido-2',3'-deoxythymidin-5'-yl phosphate 

Relevant academic research and scientific papers

Design of new mononucleotide prodrugs: Aryl (SATE) phosphotriester derivatives

Synthesis, biological activities and decomposition kinetics of novel phosphotriester derivatives of 3′-azido-2′,3′-dideoxythymidine (AZT) bearing a S-tButyl-2-thioethyl (tBuSATE) group and L-tyrosinyl residues are reported. All the derivatives appeared to

S-acyl-2-thioethyl aryl phosphotriester derivatives as mononucleotide prodrugs

The synthesis and biological activities of phosphotriester derivatives of 3′-azido-2′,3′-dideoxythymidine (AZT) bearing a phenyl group or L-tyrosinyl residues are reported. The target compounds were obtained via either PV or PIII che

Rational design of a new series of mixed anti-HIV pronucleotides

MonoSATE aryl phosphotriesters of AZT are able to deliver intracellularly the corresponding 5'-mononucleotide. This process requires activation by an esterase followed by a phosphodiesterase. This finding opens the way to the design of new pronucleotide s