153121-88-1

Basic information

• Product Name: S-2-hydroxyethyl 2,2-dimethylpropanethioate
• Synonyms: S-2-hydroxyethyl 2,2-dimethylpropanethioate;2,2-Dimethylpropanethioic acid S-(2-hydroxyethyl) ester;1-[(2-hydroxyethyl)sulfanyl]-2,2-dimethylpropan-1-one
• CAS NO: 153121-88-1
• Molecular Formula: C₇H₁₄O₂S
• Molecular Weight: 162.24986
• Mol File: 153121-88-1.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: S-2-hydroxyethyl 2,2-dimethylpropanethioate(CAS DataBase Reference)
• NIST Chemistry Reference: S-2-hydroxyethyl 2,2-dimethylpropanethioate(153121-88-1)
• EPA Substance Registry System: S-2-hydroxyethyl 2,2-dimethylpropanethioate(153121-88-1)

Safety Data

• Hazardous Substances Data: 153121-88-1(Hazardous Substances Data)

Usage

General Description

S-2-hydroxyethyl 2,2-dimethylpropanethioate, is a chemical compound predominantly used as an intermediate during the synthesis of other chemicals. It belongs to the chemical class known as thioesters, which consists of compounds characterized by the presence of a sulfur atom bonded to a carbon atom. This synthetic ingredient is rarely observed naturally. Its molecular formula is C7H14O2S and it is also known by its systematic IUPAC name, S-(2-hydroxyethyl) 2,2-dimethylpropanethioate. The key aspect of its structure is the presence of a sulfur atom which makes it potential for various chemical reactions. It is important to handle this chemical with care due to its potentially harmful effects.

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Relevant articles and documents

Mononucleoside Phosphotriester Derivatives with S-Acyl-2-thioethyl Bioreversible Phospate-Protecting Groups: Interacellular Delivery of 3'-Azido-2',3'-dideoxythymidine 5'-Monophosphate

The synthesis, in vitro anti-HIV-1 activity, and decomposition pathways of several mononucleoside phosphotriester derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) incorporating a new kind of carboxylate esterase-labile transient phosphate-protecting group, namely S-acyl-2-thioethyl, are reported.All the described compounds showed marked antiviral activity in thymidine kinase-deficient CEM cells in which AZT was virtually inactive.The results strongly support the hypothesis that such pronucleotides exert their biological effects via intracellular delivery of the 5'-mononucleotide of AZT.This point was corroborated by decomposition studies in cell extracts and culture medium.

CYCLOBUTYL PURINE DERIVATIVE OR SALT THEREOF

An object of the present invention is to provide a compound exhibiting an excellent drug efficacy as an anti-adenoviral agent, and an anti-adenoviral agent. The present invention provides a compound represented by General Formula [1] (in the formula, R1 represents a halogen atom, an amino group which may be substituted, a C1-6 alkoxy group which may be substituted, a hydroxyl group which may be protected, or the like; R2 represents a hydrogen atom or an amino protecting group; R3 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like; R4 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like); or a salt thereof.

PHOSPHORODIAMIDATES AND OTHER PHOSPHORUS DERIVATIVES OF FINGOLIMOD AND RELATED S1 P RECEPTOR MODULATORS

Compounds of general formula (I): (Formula I)) wherein R1, Q, R3, R4, R5, R6, R7 and Ar1 are as defined herein are inhibitors of class I histone deacetylases and are of use in th