85545-58-0

Basic information

• Product Name: 1,2,4-Benzenetriamine, N4,N4-dimethyl-
• Synonyms: 1,2,4-Benzenetriamine, N4,N4-dimethyl-
• CAS NO: 85545-58-0
• Molecular Formula: C₈H₁₃N₃
• Molecular Weight: 151.21
• Mol File: 85545-58-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 296.0±20.0 °C(Predicted)
• Appearance: /
• Density: 1.145±0.06 g/cm3(Predicted)
• PKA: 6.66±0.22(Predicted)
• CAS DataBase Reference: 1,2,4-Benzenetriamine, N4,N4-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Benzenetriamine, N4,N4-dimethyl-(85545-58-0)
• EPA Substance Registry System: 1,2,4-Benzenetriamine, N4,N4-dimethyl-(85545-58-0)

Safety Data

• Hazardous Substances Data: 85545-58-0(Hazardous Substances Data)

Usage

Chemical structure

1,2,4-Benzenetriamine, N4,N4-dimethyl-

Physical state

Colorless to pale yellow liquid

Explanation

The compound is in a liquid state at room temperature, with a color ranging from colorless to pale yellow.

Explanation

Due to its potential for causing skin and eye irritation, as well as being harmful if swallowed or inhaled, this compound is considered hazardous.

Explanation

The compound can be harmful to aquatic organisms and can persist in the environment, causing potential harm to ecosystems.

Explanation

To minimize the risk of harm to humans and the environment, it is essential to follow appropriate handling and disposal guidelines when working with this compound.

Explanation

The compound's chemical properties make it useful in various industries, including the production of polymers, dyes, and pharmaceuticals.

Hazardous classification

Classified as a hazardous substance

Environmental impact

Toxic to aquatic life and has long-lasting effects on the environment

Handling and disposal

Proper handling and disposal procedures are necessary

Applications

Used in the manufacturing of polymers, dyes, and pharmaceuticals

Upstream product

• 2369-11-1 5-fluoro-2-nitroaniline 
• 5228-61-5 5-bromo-2-nitroaniline 
• 16293-12-2 N⁴,N⁴-Dimethyl-2-nitro-1,4-phenylenediamine 
• 129195-09-1 5-(N,N-dimethylamino)-2-nitroacetamide 
• 345-14-2 N-methylcarbonyl 2-nitro-5-fluoroaniline 
• 1635-61-6 5-chloro-2-nitroaniline 
• 20691-71-8 5-(dimethylamino)-2-nitroaniline 

Downstream Products

• 152601-80-4 (E)-3-(p-13-aza-1,4,7,10-tetraoxacyclopentadecane-13-ylstyryl)-7-(N,N-dimethylamino)-1,4-benzodiazine-2-one 
• 1449690-61-2 C₁₇H₂₇N₃O₃ 
• 1339046-23-9 4-(5'-(dimethylamino)benzimidazol-2'-yl)-2-nitroaniline 
• 1339046-25-1 2-amino-4-(5'-(dimethylamino)benzimidazol-2'-yl)aniline 
• 889664-44-2 1-[5-N,N-dimethylamino-2-(2-quinolinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite 
• 889664-42-0 1-[5-N,N-dimethylamino-2-(2-pyridinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether-3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) 
• 889664-43-1 1-[5-N,N-dimethylamino-2-(2-quinolinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether 
• 909777-15-7 C₃₉H₃₆N₄O₅ 
• 889664-41-9 1-[5-N,N-dimethylamino-2-(2-pyridinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether 
• 111861-16-6 [2-(4-Amino-phenyl)-1H-benzoimidazol-5-yl]-dimethyl-amine 
• 42197-31-9 Dimethyl-[2-(4-nitro-phenyl)-1H-benzoimidazol-5-yl]-amine 
• 136415-09-3 2,6-Di-tert-butyl-4-[2-(5-dimethylamino-1H-benzoimidazol-2-yl)-ethyl]-phenol 
• 129244-56-0 2,6-Di-tert-butyl-4-(5-dimethylamino-1H-benzoimidazol-2-ylmethyl)-phenol 
• 129244-55-9 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-5⁽⁶⁾-(dimethylamino)benzimidazole 

Relevant articles and documents

Synthesis and Evaluation of Fluorine-18 Labeled 2-Phenylquinoxaline Derivatives as Potential Tau Imaging Agents

In this study, three pairs of optically pure 18F-labeled 2-phenylquinoxaline derivatives were evaluated as Tau imaging agents for the diagnosis of Alzheimer's disease (AD). The chiral 2-fluoromethyl-1,2-ethylenediol side chain was attached to the 2-phenyl

Interaction of bisbenzimidazole-substituted carbazole derivatives with G-quadruplexes and living cells

G-quadruplex (G4) ligands have potential as chemotherapeutic agents because of the important roles of G4s in regulation of genomic function. Previously, we have developed a fluorescent probe (termed as BPBC) with excellent selectivity to parallel G4s, which possesses a V-shaped bisbenzimidazole-substituted carbazole planar core and two methylpiperazine side arms. Here, we further investigated the interactions of BPBC derivatives with different DNA and living cells. The spectral analysis showed that non-substituted bisbenzimidazole-substituted carbazole (7c) and bisdimethylamino-substituted 7c (7b) exhibited good selectivity to parallel G4s. The binding affinities of BPBC derivatives to parallel G4s were BPBC > 7b 7c. BPBC and 7b entered living cells and mainly located in the cytoplasma and nucleoli; 7c mainly located in the lysosome. BPBC exhibited the highest cytotoxicity with IC50 around 1 μM. Our results suggest that the bisbenzimidazole-substituted carbazole core is the key factor for selectively binding BPBC derivatives to parallel G4s; the side arms can change their affinity to specific G4s, as well as their interaction with cells. Further optimization of the side arms will provide the opportunity to obtain chemotherapeutic agents targeting specific G4s in cells.

Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents

A series of benzimidazole based HDAC inhibitors have been rationally designed, synthesized and screened. The SAR of this new chemotype is described. The lead compound, 11e, showed strong activity in several cellular assays and demonstrated in vivo efficacy in mouse xenograft pancreatic cancer models.