20691-71-8

Basic information

• Product Name: 3-amino N,N-dimethyl 4-nitro aniline
• Synonyms: 4-Dimethylamino-1-nitro-2-benzenamine;N,N-Dimethyl-4-nitro-1,3-benzenediamine;(3-Amino-4-nitrophenyl)dimethylamine;5-Dimethylamino-2-nitroaniline;N1,N1-Dimethyl-4-nitro-1,3-benzenediamine;N1,N1-diMethyl-4-nitrobenzene-1,3-diaMine
• CAS NO: 20691-71-8
• Molecular Formula: C₈H₁₁N₃O₂
• Molecular Weight: 181.2
• Mol File: 20691-71-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: 140℃
• Boiling Point: 355℃
• Flash Point: 168℃
• Appearance: /
• Density: 1.280
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 0.75±0.22(Predicted)
• CAS DataBase Reference: 3-amino N,N-dimethyl 4-nitro aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino N,N-dimethyl 4-nitro aniline(20691-71-8)
• EPA Substance Registry System: 3-amino N,N-dimethyl 4-nitro aniline(20691-71-8)

Safety Data

• Hazardous Substances Data: 20691-71-8(Hazardous Substances Data)

Usage

General Description

3-amino N,N-dimethyl 4-nitroaniline is an organic compound with the chemical formula C8H11N3O2. It is a yellow crystalline solid that is commonly used as an intermediate in the synthesis of various dyes and pigments. This chemical is also known for its application in the production of pharmaceuticals and agrochemicals. However, it is important to handle this compound with care, as it is toxic and may cause skin and eye irritation upon contact. Additionally, it is important to use proper safety precautions and handling procedures when working with 3-amino N,N-dimethyl 4-nitroaniline due to its potential health hazards.

Upstream product

• 35998-95-9 N,N-dimethyl-3,4-dinitroaniline 
• 5228-61-5 5-bromo-2-nitroaniline 
• 506-59-2 N,N-dimethylammonium chloride 
• 110-91-8 morpholine 
• 1635-61-6 5-chloro-2-nitroaniline 
• 68-12-2 N,N-dimethyl-formamide 
• 345-14-2 N-methylcarbonyl 2-nitro-5-fluoroaniline 
• 124-40-3 dimethyl amine 
• 109-01-3 1-methyl-piperazine 
• 2369-11-1 5-fluoro-2-nitroaniline 
• 7664-41-7 ammonia 
• 129195-09-1 5-(N,N-dimethylamino)-2-nitroacetamide 
• 121-69-7 N,N-dimethyl-aniline 

Downstream Products

• 63019-99-8 4-dimethylamino-2-(phenylamino)nitrobenzene 
• 129195-09-1 5-(N,N-dimethylamino)-2-nitroacetamide 
• 1262887-26-2 N,N-dimethyl-1H-benzo[d]imidazol-6-amine 
• 1339046-23-9 4-(5'-(dimethylamino)benzimidazol-2'-yl)-2-nitroaniline 
• 1339046-25-1 2-amino-4-(5'-(dimethylamino)benzimidazol-2'-yl)aniline 
• 6124-22-7 5-Dimethylamino-benzofurazan 
• 63019-87-4 acetic acid-(2-anilino-4-dimethylamino-anilide) 
• 53666-59-4 2-Chlor-N⁴,N⁴-dimethyl-p-phenylendiamin 
• 152601-80-4 (E)-3-(p-13-aza-1,4,7,10-tetraoxacyclopentadecane-13-ylstyryl)-7-(N,N-dimethylamino)-1,4-benzodiazine-2-one 
• 889664-44-2 1-[5-N,N-dimethylamino-2-(2-quinolinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite 
• 889664-42-0 1-[5-N,N-dimethylamino-2-(2-pyridinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether-3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) 
• 889664-43-1 1-[5-N,N-dimethylamino-2-(2-quinolinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether 
• 909777-15-7 C₃₉H₃₆N₄O₅ 
• 889664-41-9 1-[5-N,N-dimethylamino-2-(2-pyridinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether 

Relevant articles and documents

Synthesis and characterization of 8-aminoquinolines, substituted by electron donating groups, as high-affinity copper chelators for the treatment of Alzheimer's disease

The deregulation of copper homeostasis generates copper–amyloid aggregation and strongly participates in neuron damage in the brains of patients with Alzheimer's disease. Therefore, copper chelators able to regulate copper homeostasis should be considered

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Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization

PRMT5 plays important roles in diverse cellular processes and is upregulated in several human malignancies. Besides, PRMT5 has been validated as an anticancer target in mantle cell lymphoma. In this study, we found a potent and selective PRMT5 inhibitor by performing structure-based virtual screening and hit optimization. The identified compound 17 (IC50 = 0.33 μM) exhibited a broad selectivity against a panel of other methyltransferases. The direct binding of 17 to PRMT5 was validated by surface plasmon resonance experiments, with a Kd of 0.987 μM. Kinetic experiments indicated that 17 was a SAM competitive inhibitor other than the substrate. In addition, 17 showed selective antiproliferative effects against MV4-11 cells, and further studies indicated that the mechanism of cellular antitumor activity was due to the inhibition of PRMT5 mediated SmD3 methylation. 17 may represent a promising lead compound to understand more about PRMT5 and potentially assist the development of treatments for leukemia indications.