855594-21-7

Usage

Functional Groups

Amino group ( \textNH2 ): Provides reactivity and potential for diverse chemical reactions.
Iodophenyl group: \textC6\textH4\textI : Adds specificity and functionality to the molecule.

Application

Organic Chemistry: Used as a building block for synthesizing various compounds.
Pharmaceutical Research: Valuable in drug development due to its unique structure.

Role in Scientific Research

Chemical Reactions and Mechanisms: Studied for its reactivity, aiding in understanding reaction pathways and mechanisms.

Significance

Innovation: Contributes to the development of new drugs and materials.
Advancement of Knowledge: Plays a vital role in expanding scientific understanding in chemistry.

Upstream product

• 540-37-4 p-aminoiodobenzene 
• 216774-64-0 [(4-iodophenylcarbamoyl)methyl]carbamic acid tert-butyl ester 
• 1052166-32-1 N-(2-azidoacetyl)-4-iodobenzenamine 

Downstream Products

• 1052166-37-6 N-(4-iodophenyl)-2-(2-(4-tritylphenoxy)acetamido)acetamide 
• 1448523-92-9 2-(4-bromophenoxy)-N-[(4-iodophenylcarbamoyl)methyl]acetamide 
• 1448523-91-8 2-(4-chlorophenoxy)-N-[(4-iodophenylcarbamoyl)methyl]acetamide 
• 1448523-94-1 2-(4-fluorophenoxy)-N-[(4-iodophenylcarbamoyl)methyl]acetamide 
• 1448524-23-9 N-[(4-iodophenylcarbamoyl)methyl]-2-m-tolyloxyacetamide 

Relevant academic research and scientific papers

NOVEL LUMINESCENT LANTHANIDE CHELATE REPORTERS, BIOSPECIFIC BINDING REACTANTS LABELLED WITH NOVEL LUMINESCENT LANTHANIDE CHELATE REPORTERS AND THEIR USE

The present invention relates to novel luminescent lanthanide chelate reporters which are formed from two to three separate lanthanide chelate moieties covalently conjugated to each other to act as an unique labelling reactant, and which can be attached to a biospecific reactant and used in various assays.

In silico and pharmacological screenings identify novel serine racemase inhibitors

d-Serine is a coagonist of the N-methyl-d-aspartate (NMDA)-type glutamate receptor and its biosynthesis is catalyzed by serine racemase (SR). The overactivation of the NMDA receptor has been implicated in the development of neurodegenerative diseases, strokes, and epileptic seizures, thus, the inhibitors of SR have potential against these pathological states. Here, we have developed novel inhibitors of SR by in silico screening and in vitro enzyme assay. The newly developed inhibitors have lower IC50 value comparing with that of malonate, one of the standard SR inhibitor. The structural features of novel inhibitors suggest the importance of central amide structure having a phenoxy substituent in their structure for the SR inhibitory activity. The present findings suggest the importance and rational development of new drugs for diseases of NMDAR overactivation.

Charge transfer chromophore-stopped [2]rotaxane through [2 + 2] cycloaddition

(Figure Presented) Three charge-transfer chromophore-terminated [2]rotaxanes were synthesized, using a high-yield [2 + 2]cycloaddition reaction in apolar solvent at room temperature. Two solvent-driving molecular shuttles were constructed, which exhibit d