85562-17-0

Upstream product

• 93639-12-4 cyclopropyl(4-nitrophenyl)methanone 
• 103-84-4 Acetanilid 
• 56924-11-9 1-(4-acetylaminophenyl)-4-chloro-1-butanone 
• 57189-90-9 (4-aminophenyl)(cyclopropyl)methanone 
• 1021-25-6 1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 
• 93639-13-5 4-chloro-4'-nitrobutyrophenone 

Downstream Products

• 749-02-0 spiperone 

Relevant academic research and scientific papers

Rapid and efficient synthesis of high-purity fluorine-18 labeled haloperidol and spiperone via the nitro precursor in combination with a new HPLC separation method

We have completed a convenient synthesis of fluorine-18 labeled butyrophenone neuroleptics from their nitro precursors. Thus, we have developed an efficient single-columm HPLC system using a C18-bonded vinyl alcohol copolymer gel (octadecyl polymer, ODP) column and strongly alkaline solvent systems for purifying of the 18F-labeled butyrophenone neuroleptics obtained by a single-stp 18F-for-nitro exchange reaction. The method has been applied to the synthesis of two typical butyrophenone neuroleptics ([18F]haloperidol and [18F]spiperone) with high purity in high yield. With information concerning the optimized conditions for the 18F-for-nitro exchange reaction, the synthetic method would be useful for synthesizing various 18F-labeled compounds.