56924-11-9

Basic information

• Product Name: Acetamide, N-[4-(4-chloro-1-oxobutyl)phenyl]-
• CAS NO: 56924-11-9
• Molecular Formula: C12H14ClNO2
• Molecular Weight: 239.702
• Mol File: 56924-11-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[4-(4-chloro-1-oxobutyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[4-(4-chloro-1-oxobutyl)phenyl]-(56924-11-9)
• EPA Substance Registry System: Acetamide, N-[4-(4-chloro-1-oxobutyl)phenyl]-(56924-11-9)

Safety Data

• Hazardous Substances Data: 56924-11-9(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 103-84-4 Acetanilid 
• 4635-59-0 4-Chlorobutanoyl chloride 

Downstream Products

• 337909-77-0 1-(4-aminophenyl)-4-chloro-1-butanone-hydrochloride 
• 93639-13-5 4-chloro-4'-nitrobutyrophenone 
• 93639-12-4 cyclopropyl(4-nitrophenyl)methanone 
• 85562-17-0 8-<4-(4-nitrophenyl)-4-oxobutyl>-1-phenyl-1,3,8-triazaspiro<4.5>decan-4-one 
• 150717-69-4 4-(4-chlorophenyl)-1-<4-(4-nitrophenyl)-4-oxobutyl>-4-piperidinol 
• 749-02-0 spiperone 
• 52-86-8 haloperidol 
• 287174-94-1 N-(4-(4-chlorobutyl)phenyl)acetamide 
• 57189-90-9 (4-aminophenyl)(cyclopropyl)methanone 
• 129355-78-8 4'-(cyclopropylcarbonyl)-N-methylacetanilide 
• 80087-36-1 1-Methyl-5-[3-(4-acetylaminobenzoyl)propyl]thio-1,2,3,4-tetrazole 
• 108060-51-1 8-[4-(Acetylamino)phenyl]-5,6-dihydro-3-methyl-imidazo[1,5-a]pyridine 
• 63237-20-7 1-(4-Amino-phenyl)-4-[ethyl-(2-hydroxy-ethyl)-amino]-butan-1-one 
• 63237-19-4 4-Amino-γ-hydroxybutyrophenon 

Relevant articles and documents

New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263

We have previously reported that dual 5-HT1A and 5-HT7 receptor ligands might find utility as treatment options for various CNS related conditions including cognitive and anxiolytic impairments. We have also more recently reported that SYA16263 has antipsychotic-like properties with an absence of catalepsy in animal models ascribed to its ability to recruit β-arrestin to the D2 receptor. However, SYA16263 also binds with very high affinity to 5-HT1AR (Ki = 1.1 nM) and a moderate affinity at 5-HT7R (Ki = 90 nM). Thus, it was of interest to exploit its pharmacophore elements in designing new dual receptor ligands. Using SYA16263 as the lead molecule, we have conducted a limited structure-affinity relationship (SAFIR) study by modifying various structural elements in the arylalkyl moiety, resulting in the identification of a new dual 5-HT1AR and 5-HT7R ligand, 6-chloro-2-methyl-2-(3-(4-(pyridin-2-yl)piperazin-1-yl)propyl)-2,3-dihydro-1H-inden-1-one (21), which unlike SYA16263, has a sub-nanomolar (5-HT1AR, Ki = 0.74 nM) and a low nanomolar (5-HT7R, Ki = 8.4 nM) affinity for these receptors. Interestingly, 21 is a full agonist at 5-HT1AR and antagonist at the 5-HT7R, functional characteristics which point to its potential as an antidepressant agent.

Novel phenylpiperazine derivatives as dual cytokine regulators with TNF-α suppressing and IL-10 augmenting activity

Phenylpiperazine derivatives were synthesized as dual cytokine regulators with TNF-α suppressing and IL-10 augmenting activity. Lead optimization led to compound 5k having the potent regulatory activity and demonstrating remarkable protective effects against the lethal challenge of LPS in mice, suggesting that 5k would be a promising drug candidate for the treatment of TNF-α associated diseases including septic shock. (C) 2000 Elsevier Science Ltd. All rights reserved.

Studies on gastric antiulcer active agents. III. Synthesis of 1-substituted 4-(5-tetrazolyl)thio-1-butanones and related compounds

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