855648-83-8Relevant academic research and scientific papers
4-hydroxy-2-quinolones. 202*. Synthesis, chemical and biological properties of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3- carboxylic acid alkylamides
Ukrainets,Bevz,Mospanova,Savchenkova,Yankovich
experimental part, p. 320 - 326 (2012/08/27)
In continuation of the search for potential analgesics amongst 4-hydroxyquinol-2-one derivatives we have proposed and carried out a preparative method of synthesis of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3- carboxylic acid alkylamides. It has been shown that bromination of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid allylamide using an equivalent of molecular bromine occurs with a conventional addition of the halogen to the allyl double bond and not with halocyclization. The results of the study of the analgesic properties of the compounds prepared are presented.
Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1
Folkes, Adrian,Brown,Canne, Lynne E.,Chan, Jocelyn,Engelhardt, Erin,Epshteyn, Sergey,Faint, Richard,Golec, Julian,Hanel, Art,Kearney, Patrick,Leahy, James W.,Mac, Morrison,Matthews, David,Prisbylla, Michael P.,Sanderson, Jason,Simon, Reyna J.,Tesfai, Zerom,Vicker, Nigel,Wang, Shouming,Webb, Robert R.,Charlton, Peter
, p. 1063 - 1066 (2007/10/03)
We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These studies resulted in the identification of several compounds which showed excellent potency against PAI-1. The design, synthesis and SAR of these compounds are described.
