855662-70-3Relevant academic research and scientific papers
D- and L-2′,3′-didehydro-2′,3′-dideoxy-3′- fluoro-carbocyclic nucleosides: Synthesis, anti-HIV activity and mechanism of resistance
Wang, Jianing,Jin, Yunho,Rapp, Kimberly L.,Schinazi, Raymond F.,Chu, Chung K.
, p. 1828 - 1839 (2008/02/04)
Introducing 2′-fluoro substitution on the 2′,3′-double bond in carbocyclic nucleosides has provided biologically interesting compounds with potent anti-HIV activity. As an extension of our previous works in the discovery of anti-HIV agents, D- and L-2′,3′
Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2′,3′-didehydro-2′,3′-dideoxy-2′- fluorocarbocyclic nucleosides
Wang, Jianing,Jin, Yunho,Rapp, Kimberly L.,Bennett, Matthew,Schinazi, Raymond F.,Chu, Chung K.
, p. 3736 - 3748 (2007/10/03)
Carbocyclic nucleosides have received much attention due to their interesting biological activity and metabolic stability. Among nucleoside analogues, a fluorine substitution on the carbohydrate moiety or introduction of a 2′,3′-unsaturated structure moti
