85576-90-5Relevant academic research and scientific papers
CHEMISTRY OF 2-BROMO-2-METHYLPROPANAMIDES. SYNTHESIS AND SOLVOLYTIC BEHAVIOUR OF OXAZOLIDINONES AND SPIRO-OXAZOLIDINONES
Scrimin, Paolo,Cavicchioni, Giorgio,D'Angeli, Ferruccio,Goldblum, Amiram,Maran, Flavio
, p. 43 - 48 (2007/10/02)
The base-promoted reaction of 2-bromo-2-methylpropanamides (1) with 5-, 6-, and 7-membered lactams (2) affords spiro-oxazolidinones (3).The latter compounds are hydrolysed under acidic conditions to yield the ω-aminoester amides (7).The solvolytic behaviour of some monocyclic oxazolidinones obtained upon reaction of common amides with 2-bromoamides (1) is also reported.
Base-promoted Reactions of α-Halogeno-alkylanilides
Cavicchioni, Giorgio,Scrimin, Paolo,Veronese, Augusto C.,Balboni, Gianfranco,D'Angeli, Ferruccio
, p. 2969 - 2972 (2007/10/02)
Hydride-promoted reactions of 2-halogeno-alkylcarboxanilides afford heterocyclic and acyclic condensation products, some of the latter compounds arising upon hydrolysis and/or rearrangement of the former ones.Competitive formation of dioxopiperazines versus oxazolidinone derivatives or their transformation products depends mainly upon the nature (primary, secondary or tertiary) of the halide moiety.Concurrent dehydrohalogenation of 2-bromo-isobutyranilides leads to unsaturated condensation products.
