855776-92-0Relevant academic research and scientific papers
Calcitonin gene-related peptide (CGRP) receptor antagonists: Pyridine as a replacement for a core amide group
Luo, Guanglin,Chen, Ling,Civiello, Rita,Pin, Sokhom S.,Xu, Cen,Kostich, Walter,Kelley, Michelle,Conway, Charles M.,MacOr, John E.,Dubowchik, Gene M.
scheme or table, p. 2917 - 2921 (2012/06/04)
In our continuing efforts to identify CGRP receptor antagonists that can be dosed orally for the treatment of migraine headache, we have investigated a pyridine bioisosteric replacement of a polar amide portion of a previous lead compound, BMS-694153. Pyr
HETEROCYCLIC ANTI-MIGRAINE AGENTS
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Page/Page column 76-78, (2008/06/13)
The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
