85585-57-5Relevant academic research and scientific papers
A New Entry to Highly Functionalized Perhydroindans via Free Radical Cyclizations
Chuang, Che-Ping,Hart, David J.
, p. 1782 - 1784 (1983)
Reductive alkylation of substituted benzoic acids followed by iodolactonization and free radical cyclization provides an efficient stereoselective route to trans-perhydroindans.
Oxidation of oximes to nitrile oxides with hypervalent iodine reagents
Mendelsohn, Brian A.,Lee, Shelley,Kim, Simon,Teyssier, Florian,Aulakh, Virender S.,Ciufolini, Marco A.
supporting information; experimental part, p. 1539 - 1542 (2009/08/07)
Iodobenzene diacetate in MeOH containing a catalytic amount of TFA efficiently oxidizes aldoximes to nitrile oxides. The latter may be trapped in situ with olefins in a bimolecular or an intramolecular mode. The new method enables the execution of tandem oxidative dearomatization of phenols/intramolecular nitrile oxide cycloaddition sequences leading to useful synthetic intermediates.
Preparation of Functionalized trans-Perhydroindans from Substituted Benzoic Acids: Reductive Alkylation-Halolactonization-Free Radical Cyclization
Chuang, Che-Ping,Gallucci, Judith C.,Hart, David J.
, p. 3210 - 3218 (2007/10/02)
Reductive alkylation of m-toluic acid (7), m-anisic acid (8), benzoic acid (9), and 2,3-dimethylbenzoic acid (31) with selected alkyl halides followed by iodolactonization and side-chain modification gave free radical precursors 13, 14, 19, 27, and 34.Tre
