85592-80-9

Basic information

• Product Name: 2-AMINO-N-(1-PHENYL-ETHYL)-BENZAMIDE
• Synonyms: AKOS B029177;AKOS BBB/058;2-AMINO-N-(1-PHENYL-ETHYL)-BENZAMIDE
• CAS NO: 85592-80-9
• Molecular Formula: C₁₅H₁₆N₂O
• Molecular Weight: 240.3
• Mol File: 85592-80-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Sparingly)
• CAS DataBase Reference: 2-AMINO-N-(1-PHENYL-ETHYL)-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-(1-PHENYL-ETHYL)-BENZAMIDE(85592-80-9)
• EPA Substance Registry System: 2-AMINO-N-(1-PHENYL-ETHYL)-BENZAMIDE(85592-80-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 85592-80-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-N-(1-PHENYL-ETHYL)-BENZAMIDE is used as a reagent for the synthesis of potent inhibitors of class III histone/protein deacetylases. These inhibitors have potential applications in the treatment of various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions. 2-AMINO-N-(1-PHENYL-ETHYL)-BENZAMIDE's ability to modulate the activity of histone deacetylases makes it a valuable tool in drug discovery and development.
Used in Anticonvulsant Agents:
2-AMINO-N-(1-PHENYL-ETHYL)-BENZAMIDE is also used to prepare agents that promote anticonvulsant activity. These agents can be used in the treatment of epilepsy and other seizure disorders. 2-AMINO-N-(1-PHENYL-ETHYL)-BENZAMIDE's potential to modulate neuronal activity and reduce seizure susceptibility makes it a promising candidate for the development of new anticonvulsant drugs.

Upstream product

• 118-48-9 isatoic anhydride 
• 618-36-0 rac-methylbenzylamine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 124264-90-0 2-nitro-N-(1-phenylethyl)benzamide 

Downstream Products

• 76285-67-1 2-[(1-Phenyl-ethylamino)-methyl]-phenylamine 
• 870102-72-0 2-[(1-naphthalenylmethylene)amino]-N-(1-phenylethyl)benzamide 
• 410536-97-9 2-[[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide 
• 568558-23-6 2,3-dihydro-3-(1-phenylethyl)-2-thioxoquinazolin-4(1H)-one 
• 134790-09-3 3-(1-phenylethyl)quinazoline-2,4(1H,3H)-dione 

Relevant articles and documents

Convenient and sequential one-pot route for synthesis of 2-thioxoquinazolinone and quinazolinobenzothiazinedione derivatives

A new and efficient synthetic process has been developed for preparation of 2-thioxoquinazolinone and quinazolinobenzothiazinedione derivatives. The related products were synthesized through reaction of isatoic anhydride, amines/anthranilic acids, and carbon disulfide (CS2) in the presence of potassium hydroxide in ethanol at reflux. Graphical abstract: [Figure not available: see fulltext.]

Zeolite-catalyzed method for the preparation of 2,3-dihydroquinazolin-4(1H) -ones

The reaction of isatoic anhydride, amines, and aldehydes in the presence of a microporous zeolite gave 2,3-dihydroquinazolin-4(1H)-one derivatives with good to excellent yield. The yield depends on the structure of the aldehyde and/or amine compound. Copyright

Sirtuin Inhibiting Compounds

Provided herein are compositions and methods for treating or preventing cancer and autoimmune diseases. Compositions comprise a sirtuin inhibitory compound that decreases the activity of a sirtuin, such as SIRT1 or Sir2. Exemplary methods comprise contact

Microwave synthesis and anticonvulsant activity of new 3-benzyl-1,2,3- benzotriazin-4(3H)-ones

Several 3-benzyl-1,2,3-benzotriazin-4(3H)-ones 1 were prepared by alkylation of 1,2,3-benzotriazin-4(3H)-one with benzyl halides in dimethylformamide in a microwave oven in moderate yields. Accompanying 1 were minor amounts of products believed to be the O-alkylated derivatives. Support for 3-benzylation is shown by an alternate synthesis of 1a from o-amino-N- benzylbenzamide by nitrous acid cyclization. The title compounds were evaluated in mice and rats in maximal electroshock (MES) and pentylenetetrazole (scMet) seizure models for anticonvulsant activity, and in the rotorod test for neurotoxicity. They were generally non-toxic. The 3- benzyl analog was the most active (maximal electroshock) compound; it's maximal electroshock ED50 value was 93 mg/kg (mouse).