855938-33-9

Upstream product

• 14191-95-8 4-cyanomethylphenol 
• 98-88-4 benzoyl chloride 
• 1080-06-4 tyrosine methyl ester 

Downstream Products

• 853925-91-4 5-hydroxy-3-(4-hydroxy-phenyl)-7-methoxy-4-oxo-4H-chromene-2-carboxylic acid 
• 552-59-0 prunetin 

Relevant academic research and scientific papers

Ruthenium-Catalyzed Selective Hydroboration of Nitriles and Imines

Ruthenium-catalyzed hydroboration of nitriles and imines is attained using pinacolborane with unprecedented catalytic efficiency. Chemoselective hydroboration of nitriles over esters is also demonstrated. A simple [Ru(p-cymene)Cl2]2 complex (1) is used as a catalyst precursor, which upon reaction with pinacolborane in situ generates the monohydrido-bridged complex [{(η6-p-cymene)RuCl}2(μ-H-μ-Cl)] 2. Further oxidative addition of pinacolborane to intermediate 2 leading to the formation of mononuclear ruthenium hydride species is suggested. Mass spectral analysis of the reaction mixture and independent experiments with phosphine-ligated ruthenium complexes indicated the involvement of mononuclear ruthenium intermediates in the catalytic cycle. Consecutive intramolecular 1,3-hydride transfers from the ruthenium center to coordinated nitrile and boronate imine ligands, leading to the reduction and resulting in the formation of diboronate amines, are proposed as a plausible reaction mechanism.

New one-carbon degradative transformation of β-alkyl-β-azido alcohols

A new transformation of 2-azido-1-hydroxy-containing compounds to nitriles with one carbon less than the starting materials by oxidation was reported. The reaction can be performed under mild conditions.