856007-80-2Relevant academic research and scientific papers
Structure-activity relationship studies of curcumin analogues
Fuchs, James R.,Pandit, Bulbul,Bhasin, Deepak,Etter, Jonathan P.,Regan, Nicholas,Abdelhamid, Dalia,Li, Chenglong,Lin, Jiayuh,Li, Pui-Kai
, p. 2065 - 2069 (2009)
Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and evaluated. The most potent compound, compound 23, showed potent growth inhibitory activities on both prostate and breast cancer lines with IC50 values in sub-micromolar range, fifty times more potent than curcumin. Curcumin analogues might be potential anti-tumor agents for breast and prostate cancers.
