856013-04-2

Usage

Uses

Used in Chemical Research:
6-Bromopyridine-2-sulfonamide is used as a research chemical for [application reason] in the field of chemistry. Its unique structure and properties make it a valuable compound for studying various chemical reactions and processes.
Used in Pharmaceutical Development:
6-Bromopyridine-2-sulfonamide is used as a potential pharmaceutical intermediate for [application reason] in the development of new drugs. Its chemical structure may offer insights into the design of novel therapeutic agents, particularly in the areas of organobromide and organosulfonic acid-based compounds.
Used in Material Science:
6-Bromopyridine-2-sulfonamide is used as a component in the synthesis of advanced materials for [application reason] in material science. Its properties may contribute to the development of new materials with unique characteristics, such as improved stability or enhanced reactivity.
It is important to handle 6-Bromopyridine-2-sulfonamide with care, as its specific effects on human health and the environment have not been fully established. Proper safety measures should be taken to minimize potential risks during its production, use, and disposal.

Upstream product

• 856013-03-1 6-bromopyridine-2(1H)-thione 
• 912934-77-1 6-bromopyridine-2-sulfonyl chloride 
• 93681-52-8 2-benzylsulphenyl-6-bromopyridine 
• 626-05-1 2,6-Dibromopyridine 
• 1135871-89-4 6-bromo-N-(tert-butyl)pyridine-2-sulfonamide 

Downstream Products

• 1135871-94-1 N-(6-phenyl-hexanoyl)-6-(8-oxo-5,6,7,8-tetrahydro-naphthalen-2-yl)-pyridine-2-sulfonamide 
• 1135870-86-8 6-[8-(benzothiazol-2-yl-hydrazono)-5,6,7,8-tetrahydro-naphthalen-2-yl]-pyridine-2-sulfonic acid 

Relevant academic research and scientific papers

Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide

We have recently disclosed 5-phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine 1 as a potent IKur current blocker with selectivity versus hERG, Na and Ca channels, and an acceptable preclinical PK profile. Upon further characterization in vivo, compound 1 demonstrated an unacceptable level of brain penetration. In an effort to reduce the level of brain penetration while maintaining the overall profile, SAR was developed at the C2′ position for a series of close analogues by employing hydrogen bond donors. As a result, 5-[5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide (25) was identified as the lead compound in this series. Compound 25 showed robust effects in rabbit and canine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile and was advanced as the clinical candidate. Further optimization of 25 to mitigate pH-dependent absorption resulted in identification of the corresponding phosphoramide prodrug (29) with an improved solubility and pharmacokinetic profile.

BENZOTHIAZOLE COMPOUNDS

The present invention relates to benzothiazole compounds that mimic the activity of BH3 only proteins and are capable of binding to and neutralizing pro survival Bcl 2 proteins. The invention also relates to the use of such compounds in the regulation of cell death or cell survival and the treatment and/or prophylaxis of diseases or conditions associated with the deregulation of cell death or cell survival.

PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES

Compounds of formula (I): Wherein: R1 is-XSO2NR6R7; wherein X is -(CH2)p - or C2-6 alkenylene; p is an integer from 0 to 6; Ar2 is a mono or bicyclic heteroaryl or a b