85603-32-3Relevant academic research and scientific papers
The synthesis of some 1,1-diphenyl-1-alkoxy-3-alkylamino-2-propanones''' of biological interest
Kourounakis,Chilliard
, p. 825 - 827 (2007/10/02)
The synthesis of 1,1-diphenyl-1-alkoxy-3-alkylamino-2-propanones is reported. For this synthesis the following series of reactions was utilized: 1-phenyl-1-propanone was brominated, the product reacted with benzene (Friedel-Crafts), the 1,1-diphenyl-3-propanone was brominated, then reacted with the appropriate alcohol, the alkoxy derivative was brominated and then reacted with the appropriate amine. The synthesized compounds were tested for analgesic activity. All test compounds showed weak analgesic action, the most active were 1,1-diphenyl-1-ethoxy-3-piperidino-2-propanone and 1,1-diphenyl-1-phenoxy-3-dimethylamino-2-propanone.
