856089-56-0Relevant academic research and scientific papers
Rhodium-catalyzed intramolecular hydroarylation of 1-halo-1-alkynes: Regioselective synthesis of semihydrogenated aromatic heterocycles
Murase, Hirohiko,Senda, Kousuke,Senoo, Masato,Hata, Takeshi,Urabe, Hirokazu
supporting information, p. 317 - 322 (2014/01/17)
The regioselective intramolecular hydroarylation of (3-halo-2-propynyl) anilines, (3-halo-2-propynyl) aryl ethers, or (4-halo-3-butynyl) aryl ethers was efficiently catalyzed by Rh2(OCOCF3)4 to give semihydrogenated aromatic heterocycles, such as 4-halo-1,2-dihydroquinolines, 4-halo-3-chromenes, or 4-(halomethylene)chromans, in good to excellent yields. Some synthetic applications taking advantage of the halo-substituents of the products are also illustrated. Ring a rhodium! Regioselective intramolecular hydroarylation of haloacetylenes efficiently catalyzed by [Rh 2(tfa)4] (see scheme; tfa=OCOCF3) gave semihydrogenated aromatic heterocycles in good to excellent yields. Copyright
