65148-06-3

Basic information

• Product Name: 3-[PHENYL-(TOLUENE-4-SULFONYL)-AMINO]-PROPIONIC ACID
• Synonyms: 3-(N-phenyl4-methylbenzenesulfonamido)propanoic acid
• CAS NO: 65148-06-3
• Molecular Formula: C₁₆H₁₇NO₄S
• Molecular Weight: 319.38
• Mol File: 65148-06-3.mol

Chemical Properties

• Boiling Point: 513.8°C at 760 mmHg
• Flash Point: 264.6°C
• Appearance: /
• Vapor Pressure: 2.21E-11mmHg at 25°C
• CAS DataBase Reference: 3-[PHENYL-(TOLUENE-4-SULFONYL)-AMINO]-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[PHENYL-(TOLUENE-4-SULFONYL)-AMINO]-PROPIONIC ACID(65148-06-3)
• EPA Substance Registry System: 3-[PHENYL-(TOLUENE-4-SULFONYL)-AMINO]-PROPIONIC ACID(65148-06-3)

Safety Data

• Hazardous Substances Data: 65148-06-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H17NO4S/c1-13-7-9-15(10-8-13)22(20,21)17(12-11-16(18)19)14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H,18,19)/p-1

Upstream product

• 62750-11-2 ethyl 3-phenylaminopropionate 
• 5652-38-0 N-phenyl-β-alanine 
• 98-59-9 p-toluenesulfonyl chloride 
• 62-53-3 aniline 
• 21911-84-2 methyl 3-(phenylamino)propanoate 
• 76263-72-4 ethyl N-tosyl-β-anilinopropionate 
• 17266-98-7 methyl 3-[N-phenyl-N-(p-toluenesulfonyl)amino]propionate 
• 107-94-8 chloropropionic acid 
• 68-34-8 phenyl toluenesulfonamide 

Downstream Products

• 611-35-8 4-chloroquinoline 
• 856089-56-0 N-(p-toluenesulfonyl)-4-chloro-1,2-dihydroquinoline 
• 14278-37-6 1-tosyl-2,3-dihydroquinolin-4(1H)-one 
• 76263-65-5 (E)-3-[1-(phenyl)-methylidene]-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-quinolin-4-one 
• 76298-68-5 2-acetyl-3-phenyl-5-tosyl-3,3a,4,5-tetrahydropyrazolo<4,3-c>quinoline 
• 367509-06-6 1-(3,4-dimethoxybenzoyl)-2,3-dihydroquinolin-4(1H)-one 
• 367509-05-5 (3,4-dimethoxyphenyl)(4-hydroxy-3,4-dihydroquinolin-1(2H)-yl)methanone 
• 607-31-8 4-methoxyquinoline 
• 30696-07-2 phenyl-quinolin-4-yl-amine 
• 155249-62-0 11-Benzyl-8-methoxy-11H-indolo[3,2-c]quinoline 
• 239-09-8 11H-indolo[3,2-c]quinoline 
• 4295-36-7 2,3-dihydroquinolin-4(1H)-one 
• 17266-98-7 methyl 3-[N-phenyl-N-(p-toluenesulfonyl)amino]propionate 

Relevant articles and documents

HETEROCYCLIC COMPOUND

The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).

Structure-activity relationships of antimalarial indoloquinolines

Structure-activity relationships have been ascertained and chemical metodology developed for a series of antimalarial 3-chloroindoloquinoline-5-oxides.The basic side chain as well as the ring N-oxide are critical for antimalarial activity as is a bromine or chlorine in position 3.Substitution at positions 7,8,9,10 in not essential, although the most potent analog in our studies was the 8-nitro compound 4vv. indoloquinolines / antimalarial agents

Studies in Antifertility Agents: Part XXVII - Synthesis of 2-Acetyl-3-aryl-5-tosyl-7/8-H (or methoxy)-3,3a,4,5-tetrahydropyrazoloquinolines

N-Tosyl-2,3-dihydro-4-quinolones (12-14), prepared from aniline, m- and p-anisidines by reported procedures, on condensation with araldehydes in the presence of NaOMe give the corresponding 3-arylidene-4-quinolones (15-18).Refluxing of 15-18 with NH2-NH2*H2O in gl.AcOH affords the title compounds, 2-acetyl-3-aryl-5-tosyl-7/8-H (or methoxy)-3,3a,4,5-tetrahydropyrazoloquinolines (19-22).The stereochemistry of the title compounds based on the assignments of C3-H, C3a-H, C4-H2 protons has been studied by PMR decoupling experiments.In preliminary screening, compounds 19 and 22 have been found to prevent pregnancy at 20 mg/kg dose in female albino rats, but are ineffective at lower doses.None of the compounds tested shows any significant pharmacological activity.