856134-22-0

Upstream product

• 210303-79-0 N¹,N³,N⁵-tris(2-nitrobenzenesulfonyl)-1,5-diamino-3-azapentane 

Downstream Products

• 859502-08-2 [1,4,7-tris-(2-nitro-benzenesulfonyl)-[1,4,7]triazecan-9-yl]-methanol 

Relevant academic research and scientific papers

Synthesis of azamacrocycles via a Mitsunobu reaction

Reaction of pernosylated diethylenetriamine and 2-substituted propane-1,3-diols in dry THF in the presence of triphenylphosphine and diisopropyl azodicarboxylate gives the corresponding protected 9-substituted 1,4,7-triazacyclodecanes. The Mitsunobu reaction was also used in the preparation of 3-substituted 1,5,9-triazacyclododecanes and macrocyclic pyridine derivatives.

NOVEL CHELATING AGENTS AND HIGHLY LUMINESCENT AND STABLE CHELATES AND THEIR USE

This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.