85614-50-2

Basic information

• Product Name: 1-(2-benzofuryl)butan-1-one
• Synonyms: 1-(2-benzofuryl)butan-1-one;2-BENZOFURANYL PROPYL KETONE;1-(2-Benzofuranyl)-1-butanone;Einecs 287-937-0
• CAS NO: 85614-50-2
• Molecular Formula: C₁₂H₁₂O₂
• Molecular Weight: 188.22248
• EINECS: 287-937-0
• Mol File: 85614-50-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 288.1±13.0 °C(Predicted)
• Appearance: /
• Density: 1.101±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-(2-benzofuryl)butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-benzofuryl)butan-1-one(85614-50-2)
• EPA Substance Registry System: 1-(2-benzofuryl)butan-1-one(85614-50-2)

Safety Data

• Hazardous Substances Data: 85614-50-2(Hazardous Substances Data)

Usage

General Description

1-(2-benzofuryl)butan-1-one, also known as 6-APB, is a synthetic chemical compound that belongs to the amphetamine and phenethylamine classes. It is commonly used as a recreational drug and is known for its stimulant and entactogenic effects, meaning it can produce feelings of euphoria, increased energy, and heightened empathy. The chemical structure of 1-(2-benzofuryl)butan-1-one is similar to MDMA, and it is often used as a substitute for this illegal drug. It is usually consumed orally in the form of tablets or capsules and is often sold under various street names such as "Benzofury" or "6-APB." Due to its psychoactive effects and potential for abuse, 1-(2-benzofuryl)butan-1-one is classified as a controlled substance in many countries.

Upstream product

• 4265-27-4 2-n-butylbenzo[b]furan 
• 1646-26-0 1-(benzo[b]furan-2-yl)ethanone 
• 75-03-6 ethyl iodide 
• 271-89-6 1-benzofurane 
• 60981-57-9 (benzofuran-2-yl)trimethylsilane 
• 141-75-3 butyryl chloride 

Downstream Products

• 256439-83-5 (2E)-methyl 3-(2-benzofuranyl)propenoate 

Relevant articles and documents

Selective Electrochemical Oxygenation of Alkylarenes to Carbonyls

An efficient electrochemical method for benzylic C(sp3)-H bond oxidation has been developed. A variety of methylarenes, methylheteroarenes, and benzylic (hetero)methylenes could be converted into the desired aryl aldehydes and aryl ketones in moderate to excellent yields in an undivided cell, using O2 as the oxygen source and lutidinium perchlorate as an electrolyte. On the basis of cyclic voltammetry studies, 18O labeling experiments, and radical trapping experiments, a possible single-electron transfer mechanism has been proposed for the electrooxidation reaction.

Selective C(sp3)?H Aerobic Oxidation Enabled by Decatungstate Photocatalysis in Flow

A mild and selective C(sp3)?H aerobic oxidation enabled by decatungstate photocatalysis has been developed. The reaction can be significantly improved in a microflow reactor enabling the safe use of oxygen and enhanced irradiation of the reaction mixture. Our method allows for the oxidation of both activated and unactivated C?H bonds (30 examples). The ability to selectively oxidize natural scaffolds, such as (?)-ambroxide, pregnenolone acetate, (+)-sclareolide, and artemisinin, exemplifies the utility of this new method.

AN EFFICIENT FRIEDEL-CRAFTS SYNTHESIS OF 2-ACYLBENZOFURANS

2-(Trimethylsilyl)benzofuran, available quantitatively from benzofuran itself, reacts rapidly with primary, secondary, and tertiary aliphatic carboxylic acid chlorides in the presence of titanium(IV) chloride at low temperature to afford the corresponding 2-acylbenzofurans in excellent yields.This approach offers significant synthetic advantage over existing routes to the title compounds.