85614-50-2

Usage

Uses

Used in Recreational Drug Industry:
1-(2-benzofuryl)butan-1-one is used as a recreational drug for its stimulant and entactogenic effects, which can lead to feelings of euphoria, increased energy, and heightened empathy. It is often consumed orally in the form of tablets or capsules and is sold under various street names such as "Benzofury" or "6-APB."

Upstream product

• 60981-57-9 (benzofuran-2-yl)trimethylsilane 
• 141-75-3 butyryl chloride 
• 4265-27-4 2-n-butylbenzo[b]furan 
• 271-89-6 1-benzofurane 
• 1646-26-0 1-(benzo[b]furan-2-yl)ethanone 
• 75-03-6 ethyl iodide 

Downstream Products

• 256439-83-5 (2E)-methyl 3-(2-benzofuranyl)propenoate 

Relevant academic research and scientific papers

Selective Electrochemical Oxygenation of Alkylarenes to Carbonyls

An efficient electrochemical method for benzylic C(sp3)-H bond oxidation has been developed. A variety of methylarenes, methylheteroarenes, and benzylic (hetero)methylenes could be converted into the desired aryl aldehydes and aryl ketones in moderate to excellent yields in an undivided cell, using O2 as the oxygen source and lutidinium perchlorate as an electrolyte. On the basis of cyclic voltammetry studies, 18O labeling experiments, and radical trapping experiments, a possible single-electron transfer mechanism has been proposed for the electrooxidation reaction.

Transition-Metal-Free Access to Heteroaromatic-Fused 4-Tetralones by the Oxidative Ring Expansion of the Cyclobutanol Moiety

Advances in the transition-metal-free cyclobutanol ring expansion to 4-tetralones under N-bromosuccinimide mediation are described. We have expanded the scope of this ring expansion methodology and investigated the effect substituents on the aromatic ring, and the cyclobutanol moiety, have on the outcome of the reaction. Limitations with certain substituents on the cyclobutanol moiety are also described. Further experimental evidence to support our mechanistic understanding is disclosed, and we now preclude the suggested involvement of a primary radical for this transformation.

Selective C(sp3)?H Aerobic Oxidation Enabled by Decatungstate Photocatalysis in Flow

A mild and selective C(sp3)?H aerobic oxidation enabled by decatungstate photocatalysis has been developed. The reaction can be significantly improved in a microflow reactor enabling the safe use of oxygen and enhanced irradiation of the reaction mixture. Our method allows for the oxidation of both activated and unactivated C?H bonds (30 examples). The ability to selectively oxidize natural scaffolds, such as (?)-ambroxide, pregnenolone acetate, (+)-sclareolide, and artemisinin, exemplifies the utility of this new method.

AN EFFICIENT FRIEDEL-CRAFTS SYNTHESIS OF 2-ACYLBENZOFURANS

2-(Trimethylsilyl)benzofuran, available quantitatively from benzofuran itself, reacts rapidly with primary, secondary, and tertiary aliphatic carboxylic acid chlorides in the presence of titanium(IV) chloride at low temperature to afford the corresponding 2-acylbenzofurans in excellent yields.This approach offers significant synthetic advantage over existing routes to the title compounds.