85619-74-5Relevant academic research and scientific papers
Acylmorphinans. A Novel Class of Potent Analgesic Agents
Mohacsi, Erno,O'Brien, Jay,Blount, John,Sepinwall, Jerry
, p. 1177 - 1180 (1985)
A series of novel 2- and 3-acylmorphinans (8-14) was synthesized in our search for a potent analgesic agent with low addiction potential.The compounds were evaluated for antinociceptive potency and receptor binding affinity.Among these compounds, the levorotatory 3-acetyl-N-(cyclopropylmethyl)morphinan (12) was found to be an orally active analgesic, comparable in potency to morphine (1), yet only weakly able to substitute for morphine (1) in morphine-dependent rats.
