Journal of Medicinal Chemistry p. 1177 - 1180 (1985)
Update date:2022-08-04
Topics:
Mohacsi, Erno
O'Brien, Jay
Blount, John
Sepinwall, Jerry
A series of novel 2- and 3-acylmorphinans (8-14) was synthesized in our search for a potent analgesic agent with low addiction potential.The compounds were evaluated for antinociceptive potency and receptor binding affinity.Among these compounds, the levorotatory 3-acetyl-N-(cyclopropylmethyl)morphinan (12) was found to be an orally active analgesic, comparable in potency to morphine (1), yet only weakly able to substitute for morphine (1) in morphine-dependent rats.
View MoreQuzhou Aokai Chemical Co., Ltd.
Contact:86-570-3032832
Address:NO.16 , Laodong Road,Quzhou City, Zhejiang Province,China
Contact:+86-0592 5353131
Address:No.56 Guani Road Software Park 2,Siming District
Contact:+33-5-34012600
Address:28 ZA des Pignès
Nanjing Zelang Medical Technology Co. Ltd
Contact:86-25-83063290/13770714480
Address:Ganjiabian 108# 01 Unit,701-702 room,Yao Hua Street,Qixia District,Nanjing,Jiangsu,China
qingdao goldenchem imp and exp co.,ltd.
Contact:532-55579246
Address:no.62 ,haier road laoshan distirct
Doi:10.1021/jo01184a003
(1944)Doi:10.1016/j.bmcl.2005.08.001
(2005)Doi:10.1002/hlca.19850680803
(1985)Doi:10.1111/j.1365-2621.2002.tb09451.x
(1894)Doi:10.1002/jhet.5570200117
(1983)Doi:10.1021/jo01183a005
(1944)
