85620-08-2Relevant academic research and scientific papers
An expeditious and environmentally benign methodology for the synthesis of substituted indoles from cyclic enol ethers and enol lactones
Singh, Pankajkumar R.,Surpur, Mandar P.,Patil, Sachin B.
, p. 3335 - 3340 (2008/09/21)
A simple and environmentally friendly method is developed for the synthesis of substituted indoles from commercially available aryl hydrazines and cyclic enol ethers with Montmorillonite-K10 as a heterogeneous catalyst. The catalyst is non-toxic, inexpensive and recyclable and the process is clean, high yielding and operationally simple.
A General Synthesis of Substituted Indoles from Cyclic Enol Ethers and Enol Lactones
Campos, Kevin R.,Woo, Jacqueline C. S.,Lee, Sandra,Tillyer, Richard D.
, p. 79 - 82 (2007/10/03)
(Equation presented) A general method was developed for the one-pot synthesis of highly functionalized indoles from simple, commercially available aryl hydrazines and cyclic enol ethers. Enol lactones were also used as substrates, affording substituted indole acetic acid or indole propionic acid derivatives. This procedure affords 2,3-disubstituted indoles as single regioisomers from the appropriately substituted enol ether or enol lactone. This method was highlighted in the efficient synthesis of the antimigraine drug sumitriptan and the antiinflammatory drug indomethacin.
CONVERSION OF INDOLES INTO QUINOLINES THROUGH THE N-1-C-2 FISSION BY SINGLET-OXYGEN AS A MODEL EXPERIMENT OF BIOMIMETIC SYNTHESIS OF QUININE ALKALOIDS
Ihara, Masataka,Noguchi, Kazuharu,Fukumoto, Keiichiro,Kametani, Tetsuji
, p. 2109 - 2114 (2007/10/02)
Photo-oxygenation of indole-3-acetaldehydes (28-30) followed by treatments with dimethyl sulphide and then dilute acetic acid gave 4-acylquinolines (13, 31 and 32), respectively.
