85620-74-2

Upstream product

• 100-52-7 benzaldehyde 
• 54664-07-2 1-(2-diphenylphosphinoylethyl)morpholine 
• 114893-66-2 threo-2-diphenylphosphinoyl-3-morpholino-1-phenylpropyl dimethyl-t-butylsilyl ether 
• 2096-78-8 vinyldiphenylphosphine oxide 
• 114893-66-2 erythro-2-diphenylphosphinoyl-3-morpholino-1-phenylpropyl dimethyl-t-butylsilyl ether 

Downstream Products

• 63541-20-8 4-(3-phenyl-allyl)-morpholine 
• 63541-20-8 4-[(2Z)-3-phenylprop-2-en-1-yl]morpholine 
• 114893-80-0 (Z)-1-(3-phenylallyl)morpholine hydrochloride 
• 6298-87-9 (E)-1-(3-phenylallyl)morpholine hydrochloride 

Relevant academic research and scientific papers

Horner-Wittig Reactions of β-Aminoalkyl- and β-N-Acylaminoalkyldiphenylphosphine Oxides: Synthesis of N-Allyl Amines and Amides and 5-Diphenylphosphinoyl-2-phenyl-5,6-dihydro-4H-1,3-oxazines

Lithium derivatives of β-diphenylphosphinoyl-alkyl amines and dilithium derivatives of the corresponding amides combine with aldehydes or ketones in the Horner-Wittig reaction.Separation of the diastereoisomeric intermediates leads to single positional and geometrical isomers of N-allyl amines and amides.Attempted rearrangement of the same intermediates in acid solution gives dihydro-oxazines or, in one cases, a γ-N-acylaminoallyl diphenylphosphine oxide.

REGIO- AND STEREOSPECIFIC SYNTHESIS OF ALLYLIC TERTIARY AMINES

E and Z allylic amines have been synthesised by stereospecific elimination of Ph2PO2- from pure diastereoisomers (3) and (4).