85622-74-8

Upstream product

• 2104-89-4 Ser-OMe 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 56-45-1 L-serin 

Downstream Products

• 218947-49-0 2-[(3-chloro-propyl)-(4-methoxy-benzenesulfonyl)-amino]-acrylic acid methyl ester 
• 218947-48-9 2-[(3-chloro-propyl)-(4-methoxy-benzenesulfonyl)-amino]-3-hydroxy-propionic acid methyl ester 
• 233754-49-9 methyl 3-Hydroxy-2-[(4-methoxybenzenesulfonyl)-(2-nitrobenzyl)-amino]propionate 
• 233755-00-5 (D,L) N-(4-methoxybenzenesulfonyl)-O-(2-tetrahydropyranyl)serine, methyl ester 
• 233755-13-0 methyl 3-Hydroxy-2-[(4-methoxybenzenesulfonyl)-(5-methyl-2-nitrobenzyl)amino]propionate 
• 218947-50-3 4-benzyl-1-(4-methoxy-benzenesulfonyl)-[1,4]diazepane-2-carboxylic acid methyl ester 
• 218947-52-5 1-(4-methoxy-benzenesulfonyl)-[1,4]diazepane-2-carboxylic acid methyl ester 
• 233754-60-4 methyl 2-{[2-(4-biphenylcarbonyl)aminobenzyl]-(4-methoxybenzenesulfonyl)amino}acrylate 
• 233754-93-3 1-(4-biphenylcarbonyl)-4-(4-methoxybenzenesulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylic acid 
• 233754-73-9 methyl 1-(4-biphenylcarbonyl)-4-(4-methoxybenzenesulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate 
• 522623-83-2 4-(4-methoxy-benzenesulfonyl)-1-[(4-methyl-piperazin-1-yl)-acetyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid 

Relevant academic research and scientific papers

ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS

Compound of the formula (B) are useful in treating disease conditions mediated by TNF- alpha , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

2, 3, 4, 5-TETRAHYDRO-1H-[1, 4] BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS

Compounds having formula (1) are useful in treating disease conditions mediated by matrix metalloproteinases and TACE, such as tumor growth, osteoarthritis, rheumatoid arthritis and degenerative cartilage loss.

2,3,4,5-tetrahydro-1H-(1,4)benzodiazepine-3-hydroxamic acids

Compounds having the following formula: ? are useful in treating disease conditions mediated by matrix metalloproteinases and TACE, such as tumor growth, osteoarthritis, rheumatoid arthritis and degenerative cartilage loss.

Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and tace inhibitors

Compounds of the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease, degenerative cartilage loss, graft rejection, cachex

Benzodiazepine inhibitors of the MMPs and TACE

A series of benzodiazepine inhibitors of the MMPs and TACE has been developed. These compounds display an interesting selectivity profile and should be useful tools for exploring the biological relevance of such selectivity.

Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors

Compounds of the formula: are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids

Compounds are provided having the following formula: wherein R, R1, R2, R3, and R4 are defined in the specification, which have matrix metalloproteinase inhibiting activity.

The synthesis and biological activity of a novel series of diazepine MMP inhibitors

A novel series of diazepine-based hydroxamic acid inhibitors of MMP-1, MMP-9, and MMP-13 were prepared and evaluated both in vitro and in vivo.