85623-70-7

Basic information

• Product Name: N-[(4-Fluorophenyl)methylene]-2-methyl-2-propanamine N-oxide
• Synonyms: N-[(4-Fluorophenyl)methylene]-2-methyl-2-propanamine N-oxide;N-tert-Butyl-4-fluorobenzenemethanimine N-oxide
• CAS NO: 85623-70-7
• Molecular Formula: C₁₁H₁₄FNO
• Molecular Weight: 195.23
• Mol File: 85623-70-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-[(4-Fluorophenyl)methylene]-2-methyl-2-propanamine N-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(4-Fluorophenyl)methylene]-2-methyl-2-propanamine N-oxide(85623-70-7)
• EPA Substance Registry System: N-[(4-Fluorophenyl)methylene]-2-methyl-2-propanamine N-oxide(85623-70-7)

Safety Data

• Hazardous Substances Data: 85623-70-7(Hazardous Substances Data)

Upstream product

• 91416-53-4 2-(tert-butyl)-3-(4-fluorophenyl)-1,2-oxaziridine 
• 594-70-7 2-Methyl-2-nitropropane 
• 459-57-4 4-fluorobenzaldehyde 
• 16649-50-6 N-tert-Butylhydroxylamine 
• 57497-39-9 N-tertbutylhydroxylamine hydrochloride 
• 125640-89-3 N-(4-fluorobenzyl)-tert-butylamine 

Downstream Products

• 95449-00-6 C₁₇H₁₉FNO 
• 112852-96-7 5-fluoro-2, 3-diphenyl-1H-inden-1-one 
• 2406-25-9 di-tert-butyl nitroxide 
• 16649-50-6 N-tert-Butylhydroxylamine 
• 459-57-4 4-fluorobenzaldehyde 

Relevant articles and documents

PBN (phenyl-N-tert-butylnitrone)-derivatives are effective in slowing the visual cycle and rhodopsin regeneration and in protecting the retina from light-induced damage

A2E and related toxic molecules are part of lipofuscin found in the retinal pigment epithelial (RPE) cells in eyes affected by Stargardt's disease, age-related macular degeneration (AMD), and other retinal degenerations. A novel therapeutic approach for t

Stereoselective synthesis of fluoroalkenoates and fluorinated isoxazolidinones: N-substituents governing the dual reactivity of nitrones

α-Fluoroalkenoates and 4-fluoro-5-isoxazolidinones are of vast interest due to their potential biological applications. We now demonstrate the syntheses of (E)-α-fluoroalkenoates and 4-fluoro-5-isoxazolidinones by the reactions between nitrones and α-fluoro-α-bromoacetate. By altering N-substituents in nitrones, (E)-α-fluoroalkenoates and 4-fluoro-5-isoxazolidinones can be achieved, respectively, with high chemo- and stereoselectivities. Experimental and computational studies have been conducted to elucidate the reaction mechanisms. Linear free energy relationship studies further revealed that the N-substituent effects are primarily of electronic origin. Copyright

Activation of C-H bonds in nitrones leads to iridium hydrides with antitumor activity

We report the design and synthesis of a series of new cyclometalated iridium hydrides derived from the C-H bond activation of aromatic nitrones and the biological evaluation of these iridium hydrides as antitumor agents. The nitrone ligands are based on the structure of a popular antioxidant, α-phenyl-N-tert-butylnitrone (PBN). Compared to cisplatin, the iridium hydrides exhibit excellent antitumor activity on HepG2 cells. The metal-coordinated compound with the most potent anticancer activity, 2f, was selected for further analysis because of its ability to induce apoptosis and interact with DNA. During in vitro studies and in vivo efficacy analysis with tumor xenograft models in Institute of Cancer Research (ICR) mice, complex 2f exhibited antitumor activity that was markedly superior to that of cisplatin. Our results suggest, for the first time, that metal hydrides could be a new type of metal-based antitumor agent.