85624-03-9

Upstream product

• 104-47-2 p-methoxybenzylnitrile 
• 106-95-6 allyl bromide 
• 85624-02-8 2-(4-Methoxy-phenyl)-2-phenylsulfanyl-pent-4-enenitrile 
• 58327-36-9 α-Bromo-α-(4-methoxyphenyl)acetonitrile 
• 109-72-8 n-butyllithium 
• 1195-42-2 N-cyclohexylisopropylamine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 3509-01-1 2-cyano-pent-4-enoic acid ethyl ester 
• 104-01-8 4-Methoxyphenylacetic acid 
• 4693-91-8 4-methoxyphenyl-acetic chloride 

Downstream Products

• 85624-04-0 (+/-)-α-allyl-α-(p-methoxyphenyl)acetaldehyde 
• 69300-56-7 benzyl 2-(4-methoxy)phenyl-4-pentenylamine 
• 1043416-19-8 2-allyl-2-(4-methoxyphenyl)-4-pentenenitrile 
• 75509-56-7 2-<1-(p-methoxyphenyl)-3-NN-dimethylamino>propyl-1,3-dioxolan 
• 75509-55-6 2-<1-(p-methoxyphenyl)-3-oxopropyl>-1,3-dioxolan 
• 75509-54-5 2-<1-(p-methoxyphenyl)but-3-enyl>-1,3-dioxolan 
• 75523-04-5 2-(p-methoxyphenyl)-4-(NN-dimethylamino)butanal 
• 34603-52-6 1-[2-(dimethylamino)ethyl]-4'-methoxy-2,3-dihydro-[1,1′-biphenyl]-4(1H)-one 
• 846576-85-0 benzyl[2-(4-methoxyphenyl)-4-pentenyl]amine 
• 70503-57-0 4-allyl-4-(4-methoxyphenyl)-cyclohex-2-en-1-one 

Relevant academic research and scientific papers

Lanthanide-Catalyzed Tandem Addition of Amines to Cyanoalkenes: Synthesis of Cyclic Amidines

A tandem insertion of aliphatic nitriles and unactivated alkenes to the N-H bond of secondary aliphatic amines catalyzed by simple trialkyl rare-earth metal complexes was disclosed. This reaction provides a highly atom-economic and stereoselective way to a range of cyclic amidines under mild reaction conditions.

Assembly of α-(Hetero)aryl Nitriles via Copper-Catalyzed Coupling Reactions with (Hetero)aryl Chlorides and Bromides

α-(Hetero)aryl nitriles are important structural motifs for pharmaceutical design. The known methods for direct synthesis of these compounds via coupling with (hetero)aryl halides suffer from narrow reaction scope. Herein, we report that the combination of copper salts and oxalic diamides enables the coupling of a variety of (hetero)aryl halides (Cl, Br) and ethyl cyanoacetate under mild conditions, affording α-(hetero)arylacetonitriles via one-pot decarboxylation. Additionally, the CuBr/oxalic diamide catalyzed coupling of (hetero)aryl bromides with α-alkyl-substituted ethyl cyanoacetates proceeds smoothly at 60 °C, leading to the formation of α-alkyl (hetero)arylacetonitriles after decarboxylation. The method features a general substrate scope and is compatible with various functionalities and heteroaryls.

Platinum-catalyzed intramolecular hydroamination of unactivated olefins with secondary alkylamines

Reaction of benzyl-2,2-diphenyl-4-pentenylamine with a catalytic 1:2 mixture of [PtCl2(H2C=CH2)]2 (2.5 mol %) and PPh3 in dioxane at 120 °C for 16 h led to isolation of 1-benzyl-2-methyl-4,4-diphenylp

Rearrangements of substituted 3-aza-1,2,5-hexatrienes. 3. The scope and versatility of an extremely mild 3-aza-Cope reaction

An investigation of the [3,3]-sigmatropic reaction of substituted 3-aza-1,2,5-hexatrienes to give 4-pentenenitriles is presented. This reaction has been found to occur under a wide variety of reactions conditions (10 are reported) starting from readily av

ALLYLATION AND OXIDATION REACTIONS PROMOTED BY COBALT(ll) COMPLEXES.

Two examples of radical reactions involving cobalt complexes are described.The first one concerns the reactions of allylcobaloximes with 2-bromo 2-phenylacetonitriles leading to the corresponding monoallyl derivatives.It is shown that both the rate and regioselectivity of the reactions are affected by the nature of the substituents on the phenyl group : electron-withdrawing groups give higher rates and highly regiospecific reactions.The second type of radical reactions wich finds useful synthetic applications is the oxidation of phenols by O2 catalysed by Schiff base cobalt complexes.By choosing carefully the catalyst and the solvent, these oxidations can be highly selective, quinones being the major oxidation products in most cases.

Applications of Substituted Arylacetaldehydes in the Total Synthesis of seco-Mesembrane Alkaloids. Part 1. The Total Synthesis of (+/-)-O-Methyljoubertiamine

The substituted arylacetaldehyde 2-(p-methoxyphenyl)-5-dimethylaminobutanol (1a) is shown to serve as a precursor in the total synthesis of the seco-mesembrane alkaloid (+/-)-O-methyljoubertiamine (2; R1R2=O, R3=Me, Δ

Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity

A series of novel pyrimido[2,1-a]isoquinoline derivatives is provided for use as inhibitors of allergic reactions. The compounds exhibit antiallergy activity by both oral and parenteral routes of administration.