34603-52-6

Upstream product

• 75523-04-5 2-(p-methoxyphenyl)-4-(NN-dimethylamino)butanal 
• 78-94-4 methyl vinyl ketone 
• 53484-50-7 p-methoxycinnamyl alcohol 
• 123-11-5 4-methoxy-benzaldehyde 
• 66336-61-6 1-(4-methoxyphenyl)cyclohexen-4-ol 
• 17159-98-7 3-(4-methoxyphenyl)-2-cyclohexen-1-one 
• 67019-53-8 1-(2-(dimethylamino)ethyl)-4′-methoxy-1,2,3,4-tetrahydro-[1,1′-biphenyl]-4-ol 
• 117360-96-0 3-<(1-methylpropyl)oxy>-2-cyclohexen-1-one 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 67019-55-0 2-(4'-methoxy-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)-N,N-dimethylacetamide 
• 67019-56-1 4'-methoxy-3,4,5,6-tetrahydro-[1,1'-biphenyl]-3-ol 
• 70068-11-0 1-(4-methoxy-phenyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-propan-1-one 
• 82732-20-5 1-(4-methoxyphenyl)-4-acetoxy-cis-bicyclo<4.2.0>octan-7-one 
• 82732-25-0 Acetic acid (1R,6S)-7,7-dichloro-6-(4-methoxy-phenyl)-8-oxo-bicyclo[4.2.0]oct-3-yl ester 

Downstream Products

• 34603-53-7 1-[2-(dimethylamino)ethyl]-4'-hydroxy-2,3-dihydro-[1,1'-biphenyl]-4(1H)-one 
• 6027-23-2 2-(4-methoxyphenyl)-N,N-dimethylethylamine hydrochloride 

Relevant academic research and scientific papers

TRANSITION METAL MEDIATED ASYMMETRIC SYNTHESIS, PART 15. DIRECTING GROUP COMPETITION IN ORGANOIRON INTERMEDIATES IN THE SYNTHESIS OF (+/-)-O-METHYLJOUBERTIAMINE

Directing groups work first in concert and then in competition to control the introduction of aryl and 2-dimethylaminoethyl groups by a sequence of two nucleophile additions to cationic tricarbonyl(η5-cyclohexadienyl)iron(1+) intermediates in a

Concise Total Syntheses of (±)-Joubertiamine, (±)- O -Methyljoubertiamine, (±)-3′-Methoxy-4′- O -methyljoubertiamine, (±)-Mesembrane, and (±)-Crinane

A method to access cis-3a-aryloctahydroindole alkaloids has been developed through a key strategy involving Eschenmoser-Claisen rearrangement of allylalcohol. This approach gives us an opportunity to access the all-carbon quaternary center required for ci

Synthesis of (+/-)-Mesembranol and (+/-)-O-Methyljoubertiamine. Aza-Ring Expansion of cis-Bicyclooctanones

The Syntheses of (+/-)-mesembranol (1) and (+/-)-O-methyljoubertiamine (2) are described.Each synthesis is developed from a regio- and stereospecific heteroannelation sequence of the respective 1-arylcyclohexanes 4 and 10 to provide the 3a-aryl-cis-octahy

TOTAL SYNTHESIS OF SCELETIUM (AIZOACEAE) ALKALOIDS. THE CINNAMONITRILE ROUTE. THE TOTAL SYNTHESIS OF RACEMIC O-METHYL JOUBERTIAMINE AND MESEMBRINE

A new method of synthesis of Sceletium (Aizoaceae) alkaloids based on the introduction of a "formyl anion" equivalent at the β-position of a cinnamonitrile, followed by Robinson annulation and final modification of the resulting cyanomethyl side is described.The method has been succesfully applied to the total synthesis of racemic O-methyljoubertiamine (1) and mesembrine (2).

Applications of Substituted Arylacetaldehydes in the Total Synthesis of seco-Mesembrane Alkaloids. Part 1. The Total Synthesis of (+/-)-O-Methyljoubertiamine

The substituted arylacetaldehyde 2-(p-methoxyphenyl)-5-dimethylaminobutanol (1a) is shown to serve as a precursor in the total synthesis of the seco-mesembrane alkaloid (+/-)-O-methyljoubertiamine (2; R1R2=O, R3=Me, Δ