856255-87-3

Basic information

• Product Name: 4-methyltetrahydro-2H-pyran-4-carbonitrile
• CAS NO: 856255-87-3
• Molecular Weight: 125.17
• Mol File: 856255-87-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 4-methyltetrahydro-2H-pyran-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyltetrahydro-2H-pyran-4-carbonitrile(856255-87-3)
• EPA Substance Registry System: 4-methyltetrahydro-2H-pyran-4-carbonitrile(856255-87-3)

Safety Data

• Hazardous Substances Data: 856255-87-3(Hazardous Substances Data)

Usage

General Description

4-Methyltetrahydro-2H-pyran-4-carbonitrile is a chemical compound with the molecular formula C7H11NO. It is a nitrile with a pyran ring structure, and a methyl group attached to the tetrahydro-pyran ring. 4-methyltetrahydro-2H-pyran-4-carbonitrile is often utilized in organic synthesis as a versatile building block due to its reactivity and unique structure. It can undergo various chemical transformations to yield a wide range of derivatives, making it valuable for the production of pharmaceuticals, agrochemicals, and other fine chemicals. 4-Methyltetrahydro-2H-pyran-4-carbonitrile has also demonstrated activities in biological processes, and research into its potential applications continues in various fields.

Upstream product

• 134419-59-3 4-oxanyl methanesulfonate 
• 848821-06-7 4-cyanotetrahydro-2H-pyran-4-carboxylic acid 
• 25637-16-5 4-bromotetrahydro-2H-pyran 
• 97986-34-0 toluene-4-sulfonic acid tetrahydropyran-4-yl ester 
• 4295-99-2 tetrahydro-2H-pyran-4-carbonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 65626-24-6 (4-methyltetrahydro-2H-pyran-4-yl)methanamine 
• 233276-38-5 4-methyltetrahydro-2H-pyran-4-carboxylic acid 
• 1263374-99-7 6-bromo-N-((4-methyltetrahydro-2H-pyran-4-yl)methyl)pyridin-2-amine 
• 1270076-83-9 6-(benzyloxy)-3-fluoro-N-((4-methyltetrahydro-2H-pyran-4-yl)methyl)pyridin-2-amine 

Relevant articles and documents

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

4-substituted or unsubstituted tetrahydropyran-4-carboxylic acid or its ester compound compd.

A process for producing a 4-(un)substituted tetrahydropyran-4-carboxylic acid compound or an ester compound thereof which are represented by the formula (1): (1) (wherein R represents hydrogen or a hydrocarbon group; R represents hydrogen or an optionally substituted hydrocarbon group; and R represents hydrogen or a hydrocarbon group), characterized by reacting a 4-(un)substituted 4-cyanotetrahydropyran compound represented by the formula (2): (2) (wherein R and R are the same as defined above) with water or an alcohol which are represented by the formula (3): ROH (3) (wherein R is the same as defined above) in the presence of an acid or base.

NOVEL SUBSTITUTED INDANES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS DRUGS

The invention relates to substituted indanes and derivatives thereof, to physiologically acceptable salts and physiologically functional derivatives thereof, to the production thereof, to drugs containing at least one substituted indane according to the invention or derivative thereof, and to the use of the substituted indanes according to the invention and to derivatives thereof as MCH antagonists.