85642-11-1Relevant academic research and scientific papers
An iminocoumarin sulfonamide based turn-on fluorescent probe for the detection of biothiols in aqueous solution
Yang, Yan-Ling,Zhang, Fu-Ming,Wang, Ya-Wen,Zhang, Bao-Xin,Fang, Ran,Fang, Jian-Guo,Peng, Yu
, p. 422 - 426 (2015)
A new chemodosimeter for the highly selective sensing and imaging of biothiols was designed and realized in phosphate-buffered saline solution at pH 7.4 through a fluorescence "off-on" response. A unique mechanism featuring a two-step cascade (biothiols H
Rationally designed fluorescence turn-on sensors: A new design strategy based on orbital control
Jung, Hyo Sung,Ko, Kyoung Chul,Lee, Jae Hong,Kim, Sang Hoon,Bhuniya, Sankarprasad,Lee, Jin Yong,Kim, Youngmee,Kim, Sung Jin,Kim, Jong Seung
experimental part, p. 8552 - 8557 (2010/12/19)
Herein, we explore a new strategy in the chemo-sensor field for fluorescence amplification upon binding with metal ions based on controlled participation of the nitrogen lone pair orbital. The basic architecture of the sensor entails a fluorophore, the sp2 hybridized nitrogen lone pair (-C=N-), and a chelator site referred to as the control part. Though nonplanar and nonfluorescent, compound IC1 achieved pseudo planarity from binding with Zn2+ as indicated by the increased fluorescence signal. Its other analogue (IC2) is also planar, and unlike IC1-Zn2+ was fluorescent with a lack of binding affinity to metal ions. The time-dependent density functional theory (TDDFT) calculations revealed that the fluorescence amplification was due to the blocking of the nitrogen lone pair orbital; unlikely geometrical rearrangements were insignificant. This could indicate a breakthrough concept in the future design of fluorescent turn-on sensors.
