63149-33-7

Basic information

• Product Name: 8-HYDROXYJULOLIDINE-9-ALDEHYDE
• Synonyms: 5h-benzo[ij]quinolizine-9-carboxaldehyde,2,3,6,7-tetrahydro-8-hydroxy-1;9-FORMYL-8-HYDROXYJULOLIDINE;9-FORMYL-2,3,6,7-TETRAHYDRO-1H,5H-BENZO[IJ]QUINOLIZIN-8-OL;8-HYDROXYJULOLIDINE-9-CARBOXALDEHYDE;8-HYDROXYJULOLIDINE-9-ALDEHYDE;8-HYDROXY-2,3,6,7-TETRAHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLINE-9-CARBALDEHYDE;8-HYDROXY-2,3,6,7-TETRAHYDRO-1H,5H-BENZO[I,J]QUINOLIZINE-9-CARBOXALDEHYDE;AKOS NCG-0055
• CAS NO: 63149-33-7
• Molecular Formula: C₁₃H₁₅NO₂
• Molecular Weight: 217.26
• EINECS: 263-966-4
• Product Categories: A to Z;Aldehydes;Building Blocks;C13-C60;Carbonyl Compounds;Chemical Synthesis;Dyes;Hematology and Histology;Organic Building Blocks;Stains &Stains and Dyes;T-U-V
• Mol File: 63149-33-7.mol
• Article Data: 25

Chemical Properties

• Melting Point: 69-73°C
• Boiling Point: 417.3 °C at 760 mmHg
• Flash Point: 206.2 °C
• Appearance: /
• Density: 1.3 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 9.47±0.20(Predicted)
• CAS DataBase Reference: 8-HYDROXYJULOLIDINE-9-ALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-HYDROXYJULOLIDINE-9-ALDEHYDE(63149-33-7)
• EPA Substance Registry System: 8-HYDROXYJULOLIDINE-9-ALDEHYDE(63149-33-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 63149-33-7(Hazardous Substances Data)

Usage

Uses

8-Hydroxyjulolidine-9-carboxaldehyde is a reactant in the development of iminocoumarin-based zinc sensor suitable for ratiometric fluorescence imaging of neuronal zinc.

InChI:InChI=1/C13H15NO2/c15-8-10-7-9-3-1-5-14-6-2-4-11(12(9)14)13(10)16/h7-8,16H,1-6H2

Upstream product

• 41175-50-2 8-hydroxyjulolidine 
• 68-12-2 N,N-dimethyl-formamide 
• 591-27-5 m-Hydroxyaniline 
• 109-70-6 1.3-chlorobromopropane 
• 536-90-3 m-Anisidine 
• 63468-83-7 8-methoxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline 

Downstream Products

• 83179-50-4 9.9'-carbonylbis(1,2,4,5-tetrahydro-3H,6H,10H<1>benzopyrano<9,9a,1-gh>quinolazine-10-one) 
• 129667-42-1 10-(4-nitrophenyl)-2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizine 
• 85642-11-1 coumarin 545 

Relevant articles and documents

A novel colorimetric chemosensor for Cu2+ with high selectivity and sensitivity based on rhodamine B

9-formyl-8-hydroxy-2,3,6,7-tetrahydro-1H, 5H-benzo[ij]-quinolizine rhodamine B hydrazone (FHQRH), a novel colorimetric chemosensor for Cu2+, was synthesized by a three-step synthetic route. It was found that FHQRH showed a high selectivity for Cu2+ ions and excellent anti-interference capability toward other metal ions. The FHQRH solution exhibited a visual color change after the addition of Cu2+, owing to the open spirocyclic structure via coordination with Cu2+. The complexation coefficient of FHQRH toward Cu2+ was measured to be 1:1. Furthermore, this Cu2+ chemosensor has a remarkable low detection limit of 0.45 μM, which is 2 % of the toxic level (20 μM) in drinking water as defined by the US Environment Protection Agency (EPA).

Three lysocolorimetric/lysofluorescent probes with mitochondria/lysosome dual targeting positioning

The invention discloses a preparation method of three lysocolorimetric/lysofluorescent probes with mitochondria/lysosome dual targeting positioning and application thereof in biological imaging, which belong to the technical field of chemical analysis and detection. The structure and the detection mechanism of the lysocolorimetric/lysofluorescent probes are as follows: the probes prepared have stronger solvent-induced discoloration characteristics, and the fluorescent quantum yield is relatively high. Cell experiments show that the prepared probe has a good mitochondria/lysosome positioning effect.

A general strategy for selective detection of hypochlorous acid based on triazolopyridine formation

Triazolopyridines are an important kind of fused-ring compounds. A HOCl-promoted triazolopyridine formation strategy is reported here for the first time in which hypochlorous acid (HOCl) mildly and efficiently promotes the formation of 1,2,4-triazolo[4,3-a]pyridines NT1-NT6 from various 2-pyridylhydrazones N1-N6. N6, a rhodol-pyridylhydrazone hybrid, was developed into a fluorescent probe for the selective detection of HOCl, and successfully applied to probe endogenous HOCl in living cells and zebrafish in situ and in real time. The present intramolecular cyclization reaction is selective and atom-economical, thereby not only providing an important approach for the convenient synthesis of triazolopyridines, but also offering a general strategy for sensitive, selective and biocompatible detection of endogenous HOCl in complex biosystems.