85648-06-2

Upstream product

• 91944-47-7 3,3,3-Trifluoropyruvaldehyde 
• 91944-30-8 (S)-p-<3-(cyclopropylamino)-2-hydroxypropoxy>benzaldehyde 
• 67-56-1 methanol 
• 52353-63-6 4-Hydroxymethyl-2-(4-hydroxyphenyl)-imidazole 
• 81654-33-3 5-bromo-2-(p-methoxyphenyl)-4-(trifluoromethyl)imidazole 
• 102150-93-6 (S)4-Hydroxymethyl-2-{4-[3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy]phenyl}imidazole 

Relevant academic research and scientific papers

BETA-BLOCKING SUBSTITUTED IMIDAZOLES

Novel substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and β-adrenergic blocking activity.

BETA-ADRENERGIC BLOCKING IMIDAZOLYLPHENOXY PROPANOLAMINES

Substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and β-adrenergic blocking activity. STR1

3-AMINO-2-HYDROXYPROPOXYARYL IMIDAZOLE DERIVATIVES

Novel substituted imidazoles of the formula STR1 and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and β-adrenergic blocking activity.

β1-Selective adrenoceptor antagonists: Examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class

A series of 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazoles is described. The compounds were investigated in vitro for β-adrenoceptor antagonism, and several examples were found to be selective for the β1-adrenoceptor. The structure-activity relationship exhibited by this series of compounds is discussed. (S)-2-[p-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]phenyl] -4-(2-thienyl)imidazole [(S)-13] was over 100 times more selective than atenolol for the β1-adrenergic receptor and has been selected for in-depth studies.