85655-96-5Relevant articles and documents
Direct Conversion of Internal Alkynes into α-Iodoenones: One-Step Collaborative Iodination and Oxidation
Wang, Youliang,Genoux, Alexandre,Ghorai, Subir,Chen, Hongyi,Todd, Robert,Zhang, Liming
supporting information, p. 1417 - 1420 (2016/05/19)
The reaction of an internal alkyne with 2,6-dichloropyridine N-oxide, a nucleophilic oxidant, and electrophilic N-iodosuccinimide (NIS) simultaneously enables the direct access to versatile α-iodoenones. Electronically biased internal alkynes undergo the one-step transformation with excellent regioselectivities and with practical Z/E ratios. In comparison to the related oxidative gold catalysis using pyridine N-oxides, this reaction employs NIS as the stoichiometric ynophile instead of the soft acidic noble metal catalyst and affords products featuring an additional versatile C-I bond. Similar strategies for replacing ynophilic cationic gold(I) complexes in oxidative gold catalysis with likewise ynophilic stoichiometric electrophiles would enable the development of new synthetic methods.
HOMOGENEOUS METATHESIS OF FUNCTIONALISED ACETYLENES
Villemin, Didier,Cadiot, Paul
, p. 5139 - 5140 (2007/10/02)
The first examples of functionalised acetylenes metathesis are described: (1) using molybdenum carbonyl-phenol complexes gave the expected tolane (2) and disubstituted acetylene (3).