56703-55-0

Basic information

• Product Name: 3-BUTYNYL-1-ACETATE
• Synonyms: 3-BUTYNYL-1-ACETATE;3-BUTINYL-1-ACETATE
• CAS NO: 56703-55-0
• Molecular Formula: C₆H₈O₂
• Molecular Weight: 112.13
• Product Categories: pharmacetical
• Mol File: 56703-55-0.mol

Chemical Properties

• Boiling Point: 141.7°C at 760 mmHg
• Flash Point: 39.4°C
• Appearance: /
• Density: 0.976g/cm³
• Vapor Pressure: 5.78mmHg at 25°C
• Refractive Index: 1.426
• CAS DataBase Reference: 3-BUTYNYL-1-ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BUTYNYL-1-ACETATE(56703-55-0)
• EPA Substance Registry System: 3-BUTYNYL-1-ACETATE(56703-55-0)

Safety Data

• Hazardous Substances Data: 56703-55-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H8O2/c1-3-4-5-8-6(2)7/h1H,4-5H2,2H3

Upstream product

• 75-05-8 acetonitrile 
• 927-74-2 3-Butyn-1-ol 
• 627-10-1 2-iodoethyl acetate 
• 1066-54-2 trimethylsilylacetylene 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 6564-95-0 4-oxobutyl acetate 
• 10150-87-5 1-acetoxybutan-3-one 
• 258331-45-2 Acetic acid (E)-8-benzyloxy-3-methylene-oct-4-enyl ester 
• 59377-55-8 4-Acetoxy-2-(phenylthio)butanal 
• 35602-33-6 (3E)-octenyl acetate 
• 1576-84-7 1-acetoxy-3-butene 
• 85655-96-5 4-phenylbut-3-yn-1-yl acetate 

Relevant articles and documents

IrIII-Catalyzed direct syntheses of amides and esters using nitriles as acid equivalents: A photochemical pathway

An unprecedented IrIII[df(CF3)ppy]2(dtbbpy)PF6-catalyzed simple photochemical process for direct addition of amines and alcohols to the relatively less reactive nitrile triple bond is described herein. Various amides and esters are synthesized as the reaction products, with nitriles being the acid equivalents. A mini-library of different types of amides and esters is made using this mild and efficient process, which uses only 1 mol% of photocatalyst under visible light irradiation (λ = 445 nm). The reaction strategy is also efficient for gram-scale synthesis.

Palladium-Catalyzed Cascade Intramolecular Cyclization and Allylation of Enynoates with Allylic Alcohols

A Pd(II)-catalyzed mild and highly regioselective 6-endo cyclization/allylation reaction of enynoates with simple allylic alcohols has been developed. Under mild reaction conditions, the vinyl palladium species generated in situ after cyclization could insert C-C double bond of allylic alcohol through cross-coupling reaction and lead to the formation of allyl pyrone via β-OH elimination. This cascade cross-coupling reaction represents a direct and atom economic methodology for the construction of novel allyl pyrones in moderate to good yields.

Conjugated dialkynyl-1-ol compounds, and preparation method and application thereof

The invention belongs to the technical field of pharmacochemistry, and particularly relates to conjugated dialkynyl-1-ol compounds, and a preparation method and application thereof. The preparation method of conjugated dialkynyl-1-ol compounds comprises the following steps: carrying out Cardiot-Chodkiewicz coupling reaction on (Z)-(5-bromoamyl-2-ene-4-alkynyloxy)tert-butyl diphenyl silane and alkynyl butanol to generate (Z)-9-tert-butyl-diphenylsiloxynonyl-7-ene-3,5-dialkynyl-1-ol, and carrying out alkylation reaction on the (Z)-9-tert-butyl-diphenylsiloxynonyl-7-ene-3,5-dialkynyl-1-ol to generate (Z)-9-tert-butyl-diphenylsiloxynonyl-7-ene-3,5-dialkynyl-1-alkyl ether, wherein R1=CH3(CH2)n (n=0-6), or CH2O(CH2)nCH3 (n=0-6); and carrying out deprotection on the (Z)-9-tert-butyl-diphenylsiloxynonyl-7-ene-3,5-dialkynyl-1-alkyl ether to obtain (Z)-nonyl-2-ene-4,6-dialkynyl-9-ol-1-alkyl ether, wherein R1=CH3(CH2)n (n=0-6), or CH2O(CH2)nCH3 (n=0-6).

Silica-supported boric acid catalyzed synthesis of dihydropyrimidin-2-ones, bis(indolyl)methanes, esters and amides

Silica-supported boric acid (H3BO3-SiO2) has been established as a green, efficient and recyclable catalyst for the synthesis of dihydropyrimidin-2-ones, bis(indolyl)methanes, and acetylation of alcohols, phenols, amines and thiols under solvent free conditions. The main features of the present method include clean reaction, mild conditions, low loading of environment friendly catalyst and easy workup procedure. The catalyst can be recycled at least five times without any significant loss in activity.

Discovery of an 8-aza-5-thiaProstaglandin E1 analog as a highly selective EP4 receptor agonist

For the purpose of discovering an orally available EP4 subtype-selective agonist, a series of 8-aza prostaglandin E1 (PGE1) analogs were synthesized and evaluated for their affinity for PGE2 receptor subtypes. Additionally

Ruthenium(III) acetylacetonate [Ru(acac)3] -An efficient recyclable catalyst for the acetylation of phenols, alcohols, and amines under neat conditions

A catalytic amount of ruthenium(III) acetylacetonate (2 mol%) [Ru(acac)3] enables solvent-free acetylation of phenols, alcohols, and amines at ambient temperature in good to excellent yields. Furthermore, the catalyst could be recovered and reused at least three times without a significant loss in yields.

ALKYNYL PYRROLOPYRIMIDINES AND RELATED ANALOGS AS HSP90-INHIBITORS

Alkynyl pyrrolo[2,3-d]pyrimidines and related analogs are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents used in the treatment and prevention of various HSP90 mediated disorders. Methods of synthesis and use of such compounds are also described and claimed.

A new synthesis of α-phenylseleno γ- and δ-lactones from terminal alkynes

Treatment of the hydroxy substituted (Z)-α-(phenylseleno)vinyl p-toluenesulfonates with electrophilic phenylselenenylating agents gives rise to a selenium induced ring closure reaction affording α-phenylseleno ψ- or δ-lactones.

Synthesis and Thermal Decomposition of cis-3,4,5,6-Tetrahydropyridazine-3,4-d2. Relative Rates of Rotation, Cleavage, and Closure for Tetramethylene

The stereospecific syntheses of cis-3,4,5,6-tetrahydropyridazine-3,4-d2 (6) and cis- and trans-cyclobutane-1,2-d2 are reported.The thermal decomposition of cis-3,4,5,6-tetrahydopyridazine (6) (gas phase, 439 deg C) affords 67.1 +/- 0.9percent cis-ethylene-1,2-d2, 16.1 +/- 0.8percent trans-ethylene-1,2-d2, 9.4 +/- 0.4percent cis-cyclobutane-1,2-d2, and 7.4 +/- 0.4percent trans-cyclobutane-1,2-d2.The relative rates of rotation, cleavage, and closure for this 1,2-diazene generated tetramethylene-d2 are k(cleavage)/k(closure) = 2.2 +/- 0.2 and k(rotation)/k(closure) = 12 +/- 3.An extra stereospecific cleavage component (46percent) superimposed on the 1,4-biradical pathway (54percent) from the parent tetrahydropyridazine was found, similar to that observed in the 3,4-dimethyl-3,4,5,6-tetrahydropyridazine thermal reactions.Finally, the experimental data fot the parent 1,4 biradical, tetramethylene, are compared to calculated values in the literature.