85656-55-9

Basic information

• Product Name: 2-(N-benzyl-N-methylamino)-4-(1-methylethyl)thiazole-5-carbaldehyde
• CAS NO: 85656-55-9
• Molecular Weight: 274.387
• Mol File: 85656-55-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(N-benzyl-N-methylamino)-4-(1-methylethyl)thiazole-5-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N-benzyl-N-methylamino)-4-(1-methylethyl)thiazole-5-carbaldehyde(85656-55-9)
• EPA Substance Registry System: 2-(N-benzyl-N-methylamino)-4-(1-methylethyl)thiazole-5-carbaldehyde(85656-55-9)

Safety Data

• Hazardous Substances Data: 85656-55-9(Hazardous Substances Data)

Upstream product

• 53393-11-6 1-benzyl-1-methylthiourea 
• 19967-55-6 1-bromo-3-methyl-2-butanone 
• 85656-45-7 2-(N-benzyl-N-methylamino)-4-(1-methylethyl)thiazole 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

N,N-Disubstituted 2-Aminothiazole-5-carbaldehydes: Preparation and Investigation of Structural Features

Methods of preparing N,N-disubstituted 2-aminothiazoles have been investigated. 4-Substituted N,N-dimethyl-, N-benzyl-N-methyl-, and N-methyl-N-phenyl-amines were prepared and converted by Vilsmeier formylation into 2-amino-5-carbaldehydes which were examined by i.r. and 1H n.m.r. spectrometry.The aldehyde group adopts the carbonyl O,S-syn-conformation.With the N,N-dimethyl and N-benzyl-N-methyl compounds the barrier to rotation of the amine group (ΔG(excit.)) is 50-55 kJ mol-1 and is insensitive to the nature of the 4-substituent.The amine group of the N-methyl-N-phenyl compounds has a marked preference for one orientation.This was shown by a crystallographic study of 4-t-butyl-2-(N-methyl-N-phenylamino)thiazole-5-carbaldehyde to have the phenyl group directed towards the sulphur atom of the thiazole ring.