856571-72-7Relevant articles and documents
Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate
Kiuchi, Masatoshi,Adachi, Kunitomo,Tomatsu, Ayumi,Chino, Masao,Takeda, Shuzo,Tanaka, Yoshihito,Maeda, Yasuhiro,Sato, Noriko,Mitsutomi, Naoko,Sugahara, Kunio,Chiba, Kenji
, p. 425 - 432 (2005)
A practical asymmetric synthesis of both enantiomers of the immunosuppressive FTY720-phosphate (2) was accomplished, and the enantiomers were pharmacologically evaluated. Several lipases showed considerable activity and enantioselectivity for O-acylation