85658-55-5

Basic information

• Product Name: 2-AMINO-5-BROMO-4-PHENYLPYRIMIDINE
• Synonyms: 2-AMINO-5-BROMO-4-PHENYLPYRIMIDINE;5-bromo-4-phenylpyrimidin-2-amine
• CAS NO: 85658-55-5
• Molecular Formula: C₁₀H₈BrN₃
• Molecular Weight: 250.1
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 85658-55-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 432.9°C at 760 mmHg
• Flash Point: 215.6°C
• Appearance: /
• Density: 1.566g/cm³
• Vapor Pressure: 1.07E-07mmHg at 25°C
• Refractive Index: 1.66
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.89±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-BROMO-4-PHENYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-BROMO-4-PHENYLPYRIMIDINE(85658-55-5)
• EPA Substance Registry System: 2-AMINO-5-BROMO-4-PHENYLPYRIMIDINE(85658-55-5)

Safety Data

• Hazardous Substances Data: 85658-55-5(Hazardous Substances Data)

Usage

General Description

2-Amino-5-bromo-4-phenylpyrimidine is a chemical compound with the molecular formula C10H7BrN4. It is a pyrimidine derivative, and is also known by the trade name Ibrutinib, which is a medication used to treat certain types of cancer, such as mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenstr?m's macroglobulinemia. 2-Amino-5-bromo-4-phenylpyrimidine works by inhibiting a protein called Bruton's tyrosine kinase, which plays a role in the growth and spread of cancer cells. It is typically administered orally in the form of a tablet. 2-AMINO-5-BROMO-4-PHENYLPYRIMIDINE has been the subject of ongoing research and clinical trials for its potential therapeutic applications in other types of cancer as well.

InChI:InChI=1/C10H8BrN3/c11-8-6-13-10(12)14-9(8)7-4-2-1-3-5-7/h1-6H,(H2,12,13,14)

Upstream product

• 2305-87-5 4-phenylpyrimidin-2-amine 
• 7752-82-1 5-bromo-2-aminopyrimidine 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 98-80-6 phenylboronic acid 
• 98-86-2 acetophenone 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 

Downstream Products

• 1622242-65-2 2-(4-(ethylsulfonyl)phenyl)-N-(5-(6-fluoropyridin-3-yl)-4-phenylpyrimidin-2-yl)acetamide 
• 1622243-01-9 5-(6-fluoropyridin-3-yl)-4-phenylpyrimidin-2-amine 

Relevant articles and documents

Metal free C-H functionalization of diazines and related heteroarenes with organoboron species and its application in the synthesis of a CDK inhibitor, meriolin 1

Here, we report a metal-free cross-coupling reaction of diazines and related heteroarenes with organoboron species via C-H functionalization. The optimized conditions represent a metal-free method for the activation of aryl/heteroarylboronic acids, which undergo coupling with diazines and related heteroarenes. Optimized conditions also find application in the synthesis of a pyrimidine-based potent CDK inhibitor, meriolin1.

Administration of TLR7 ligands and prodrugs thereof for treatment of infection by hepatitis C virus

This invention relates to methods for treating or preventing hepatitis C virus infections in mammals using Toll-Like Receptor (TLR)7 ligands and prodrugs thereof. More particularly, this invention relates to methods of orally administering a therapeutically effective amount of one or more prodrugs of TLR7 ligands for the treatment or prevention of hepatitis C viral infection. Oral administration of these TLR7 immunomodulating ligands and prodrugs thereof to a mammal provides therapeutically effective amounts and reduced undesirable side effects.

Transformations of 2-Aminopyrimidines and Their N-Oxides under Diazotation Conditions

The diazotation of 2-aminopyrimidines and their N-oxides in solutions with various acidities was studied.It is shown that the amino group in pyrimidine N-oxides is not diazotized in strongly acidic media and that bromination in the 5 position of the pyrimidine ring is observed in concentrated hydrobromic acid.When the reaction was carried out in moderately acidic media, it was possible to synthesize the difficult-to-obtain 2-halopyrimidine N-oxides.