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Usage

Uses

Used in Pharmaceutical Industry:
(R)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE-HCl is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical properties, including the trifluoromethyl group and the (R) stereochemistry, make it a valuable building block in the development of new drugs with specific therapeutic effects.
Used in Agrochemical Industry:
(R)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE-HCl is used as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its unique properties allow for the development of novel compounds with improved efficacy and selectivity in controlling pests and weeds.
Used in Research and Development:
(R)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE-HCl is used as a research compound to study its chemical properties and potential applications in various fields. Its chiral nature and the presence of the trifluoromethyl group make it an interesting subject for investigations in organic chemistry, medicinal chemistry, and materials science.
Used in Organic Synthesis:
(R)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE-HCl serves as a building block for the synthesis of various organic molecules, including complex natural products, pharmaceuticals, and specialty chemicals. Its unique structure and reactivity make it a versatile component in organic synthesis processes.

Upstream product

• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 1164111-43-6 C₉H₈F₃N*ClH 
• 911372-49-1 (R_S)-2-methyl-N-(1-(4-trifluoromethylphenyl)ethylidene)propane-2-sulfinamide 
• 911372-68-4 (R_S)-2-methyl-N-((R)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide 
• 911372-69-5 (R_S)-2-methyl-N-((S)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide 
• 705-31-7 4-trifluoromethylphenylacetylene 

Relevant academic research and scientific papers

Co-Catalyzed Synthesis of Primary Amines via Reductive Amination employing Hydrogen under very mild Conditions

Nanostructured and reusable 3d-metal catalysts that operate with high activity and selectivity in important chemical reactions are highly desirable. Here, a cobalt catalyst was developed for the synthesis of primary amines via reductive amination employing hydrogen as the reducing agent and easy-to-handle ammonia, dissolved in water, as the nitrogen source. The catalyst operates under very mild conditions (1.5 mol% catalyst loading, 50 °C and 10 bar H2 pressure) and outperforms commercially available noble metal catalysts (Pd, Pt, Ru, Rh, Ir). A broad scope and a very good functional group tolerance were observed. The key for the high activity seemed to be the used support: an N-doped amorphous carbon material with small and turbostratically disordered graphitic domains, which is microporous with a bimodal size distribution and with basic NH functionalities in the pores.

CARBAMATE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

Synthesis method of primary amine hydrochloride

The invention discloses a synthesis method of primary amine hydrochloride. According to the synthesis method, in the presence of a gold complex, water and alkyne carry out catalytic hydrolysis to generate ketones, and then ketones and ammonium formate are catalyzed by a rhodium complex to generate primary amine. Compared with a conventional primary amine synthesis method, the synthesis method hasthe advantages that no alkali is added during the reaction process, no side product is generated, the atomic economy is good, the reaction conditions are mild, and the synthesis method has a wide prospect.

Enantioselective hydrogenation of N-H imines

(Figure Presented) N-H ketoimines 3a-3v are readily prepared in high yield via organometallic addition to nitriles and isolated as corresponding bench-stable hydrochloride salts. Homogeneous asymmetric hydrogenation of unprotected N-H ketoimines 3a-3v usi

Reversal of diastereofacial selectivity in hydride reductions of N-tert-butanesulfinyl imines

A variety of N-tert-butanesulfinyl imines were reduced with NaBH 4 in THF containing 2% water to provide the corresponding secondary sulfinamides in high yield and diastereoselectivity. By using the same sulfinyl imine starting materials and changing the reductant to L-Selectride, the stereoselectivity could be efficiently reversed to afford the opposite product diastereomer in high yield and selectivity.