85670-20-8Relevant academic research and scientific papers
Use of N-oxide compounds in coupling reactions
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Page/Page column 12; 17; 21, (2008/12/05)
Metal-catalyzed coupling process comprising reacting a compound of general formula 1 with a compound A-X, to obtain a compound of general formula 2, which may further be converted to a compound of general formula 3
Palladium-catalyzed cross-coupling reactions of diazine N-oxides with aryl chlorides, bromides, and iodides
Leclerc, Jean-Philippe,Fagnou, Keith
, p. 7781 - 7786 (2007/10/03)
New aspects of N-oxides: Pyrazine, pyridazine, and pyrimidine N-oxides are regioselectively arylated with aryl iodides, bromides, and chlorides in the presence of a palladium catalyst (see scheme). The resulting products can be deoxygenated in high yield
Studies on Pyrazines. 9. The Facile Synthesis of Pyrazine 1-Oxides Substituted at C-2 with Cyano, Methoxycarbonyl and Carboxy Groups
Sato, Nobuhiro
, p. 169 - 171 (2007/10/02)
The peroxysulfuric acid oxidation of 2-cyanopyrazine (1) gave its 1-oxide 3 (18percent yield) and pyrazinecarboxamide (8percent yield), while that of methyl pyrazinecarboxylate (2) provided the 1- and 4-oxides in 15 and 7percent yields, respectively.On the other hand, pyrazinecarboxylic acid 1-oxide (7) was prepared by condensation of 2-methylpyrazine 1-oxide (8) with benzaldehyde followed by oxidative cleavage (47percent overall yield).
