85670-59-3Relevant academic research and scientific papers
Lewis Base–Br?nsted Acid–Enzyme Catalysis in Enantioselective Multistep One-Pot Syntheses
Giesler, Markus,Guder, Marian,Hartmann, Laura,Mantel, Marvin,Pietruszka, J?rg,Rüthlein, Elisabeth
, p. 16700 - 16706 (2021/05/07)
Establishing one-pot, multi-step protocols combining different types of catalysts is one important goal for increasing efficiency in modern organic synthesis. In particular, the high potential of biocatalysts still needs to be harvested. Based on an in-depth mechanistic investigation of a new organocatalytic protocol employing two catalysts {1,4-diazabicyclo[2.2.2]octane (DABCO); benzoic acid (BzOH)}, a sequence was established providing starting materials for enzymatic refinement (ene reductase; alcohol dehydrogenase): A gram-scale access to a variety of enantiopure key building blocks for natural product syntheses was enabled utilizing up to six catalytic steps within the same reaction vessel.
Synthetic studies on fully substituted γ-pyrone-containing natural products: Synthesis of γ-prone derivatives obtained by decomposition of peroniatriols
Arimoto,Nishiyama,Yamamura
, p. 5491 - 5494 (2007/10/02)
In connection with the two γ-pyrones obtained by decomposition reactions of peroniatriols I and II, γ-pyrone derivatives have been synthesized by newly developed mild cyclization methods, and this result revised the partial structures of these natural products.
REACTIONS OF α-HETEROATOM-SUBSTITUTED ETHERS AND SULFIDES WITH SILYL ENOL ETHERS. CHEMOSELECTIVITY IN THE CLEAVAGE OF HETEROATOM-CARBON BONDS BY IODOTRIMETHYLSILANE AND TRIMETHYLSILYL TRIFLUOROMETHANESULFONATE
Hosomi, Akira,Sakata, Yasuyuki,Sakurai, Hideki
, p. 405 - 408 (2007/10/02)
Reactions of α-heteroatom substituted ethers and related compounds (R1R2CXY; X, Y = RO, RS and Cl) with silyl enol ethers and ketene silyl acetals took place in the presence of iodotrimethylsilane (Ia) and trimethylsilyl triflate (Ib) as a catalyst and factors influencing the activation of the heteroatom by I were examined.
