85674-69-7Relevant academic research and scientific papers
Syntheses of 1-trifluoromethyl-2-naphthalenols via a novel construction of the naphthalene nucleus
Fung, Steven,Abraham, Nedumparambil A.,Bellini, Francesco,Sestanj, Kazimir
, p. 368 - 371 (2007/10/02)
A relative simple and efficient synthesis of the hitherto unknown 1-trifluoromethyl-2-naphthalenols is described.Easily acsessible benzoid precursors 6 and 7 were converted to the oximino-ketones 8 and 9 by nitrosation.A novel cyclization and hydrolysis a
6-(Lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxaldehydes
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, (2008/06/13)
A process and intermediates for preparing 6-(lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxylic acid derivatives are disclosed. The derivatives are useful for preparing aldose reductase inhibitors. With reference to the process, 1,1,1-trifluoro-5-(2-methylphenyl)-2,3-pentadione 3-oxime is cyclized to give a key intermediate 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)-2(1H)-naphthalenone oxime; and 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)-2(1H)-naphthalenone is aromatized to 5-methyl-1-(trifluoromethyl)-2-naphthalenol with a dehydrating agent.
