856758-58-2

Basic information

• Product Name: Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)-
• Synonyms: Benzenemethanamine, 4-chloro-2-fluoro-α-methyl-, (αR)-;4-chloro-2-fluoro-a-Methyl-;(R)-1-(4-chloro-2-fluorophenyl)ethanamine;BENZENEMETHANAMINE, 4-CHLORO-2-FLUORO-ALPHA-METHYL-, (ALPHAR)-;Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)-
• CAS NO: 856758-58-2
• Molecular Formula: C₈H₉ClFN
• Molecular Weight: 173.617
• Product Categories: API intermediates
• Mol File: 856758-58-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)-(856758-58-2)
• EPA Substance Registry System: Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)-(856758-58-2)

Safety Data

• Hazardous Substances Data: 856758-58-2(Hazardous Substances Data)

Usage

General Description

Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)-, also known as aR-(4-chloro-2-fluoro-α-methylbenzylamine), is a chemical compound used in pharmaceutical research and development. It is commonly utilized in the synthesis of various drug molecules, notably in the formation of potential therapeutic agents for the treatment of diseases such as cancer, cardiovascular disorders, and neurological conditions. Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)- is a chiral molecule, meaning it exists in two distinct mirror-image forms, and its stereochemistry plays a critical role in its pharmacological activity. As a result, aR-(4-chloro-2-fluoro-α-methylbenzylamine) is of particular interest in the pharmaceutical industry for its potential as a building block in the creation of new and effective medications.

Upstream product

• 175711-83-8 4’-chloro-2’-fluoroacetophenone 
• 856562-68-0 (S)-N-((R)-1-(4-chloro-2-fluorophenyl)ethyl)-2-methylpropane-2-sulfinamide 
• 1442445-18-2 (S)-N-(1-(4-chloro-2-fluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide 

Downstream Products

• 1442445-26-2 (R)-5-bromo-N-(1-(4-chloro-2-fluorophenyl)ethyl)-2-nitroaniline 
• 1442445-27-3 (R)-5-bromo-N-(1-(4-chloro-2-fluorophenyl)ethyl)benzene-1,2-diamine 
• 1442445-28-4 (R)-6-bromo-1-(1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazole 
• 1442445-29-5 (R)-tert-butyl 4-(1-(1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 1442445-30-8 (R)-1-(1-(4-chloro-2-fluorophenyl)ethyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazole 
• 1442445-31-9 (R)-tert-butyl 2-(4-(1-((R)-1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)pyrrolidine-1-carboxylate 
• 1442445-02-4 (4-(1-((R)-1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-pyrrolidin-2-yl)methanone 
• 1442445-36-4 1-((R)-1-(4-chloro-2-fluorophenyl)ethyl)-6-((R)-3-methylpiperazin-1-yl)-1H-benzo[d]imidazole 
• 1442445-37-5 (R)-tert-butyl 2-((R)-4-(1-((R)-1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-2-methylpiperazine-1-carbonyl)pyrrolidine-1-carboxylate 
• 1442445-07-9 ((R)-4-(1-((R)-1-(4-chloro-2-fluorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-2-methylpiperazin-1-yl)((R)-pyrrolidin-2-yl)methanone 

Relevant articles and documents

SUBSTITUTED BENZIMIDAZOLES AND BENZOPYRAZOLES AS CCR(4) ANTAGONISTS

Benzimidazole, benzopyrazole and benzotriazole compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.