85676-48-8Relevant academic research and scientific papers
Precursor-Directed Diversification of Cyclic Tetrapeptidic Pseudoxylallemycins
Guo, Huijuan,Schmidt, Alexander,Stephan, Philipp,Ragu?, Luka,Braga, Daniel,Kaiser, Marcel,Dahse, Hans-Martin,Weigel, Christiane,Lackner, Gerald,Beemelmanns, Christine
, p. 2307 - 2311 (2018/10/15)
Cyclic peptides containing non-proteinogenic amino acids often exhibit a broad bioactivity spectrum and many have entered clinical trials with good prospects for drug development. We recently reported the discovery of six cyclic tetrapeptides, pseudoxylallemycins A–F (1–6), from a termite-associated Pseudoxylaria sp. X802. These compounds contain a rare O-homoallenyl-l-tyrosine moiety and show promising antimicrobial activity against the Gram-negative pathogenic bacterium Pseudomonas aeruginosa. To perform more detailed structure–activity studies, we pursued a precursor-directed diversification strategy. Herein, we report the purification, identification, and testing of 21 new pseudoxylallemycin derivatives.
One-pot isomerization-cross metathesis-reduction (ICMR) synthesis of lipophilic tetrapeptides
Jida, Mouhamad,Betti, Cecilia,Schiller, Peter W.,Tourwe, Dirk,Ballet, Steven
supporting information, p. 342 - 351 (2014/08/05)
An efficient, versatile and rapid method toward homologue series of lipophilic tetrapeptide derivatives (herein, the opioid peptides H-TIPP-OH and H-DIPP-OH) is reported. High atom economy and a minimal number of synthetic steps resulted from a one-pot ta
