10513-05-0Relevant articles and documents
Precursor-Directed Diversification of Cyclic Tetrapeptidic Pseudoxylallemycins
Guo, Huijuan,Schmidt, Alexander,Stephan, Philipp,Ragu?, Luka,Braga, Daniel,Kaiser, Marcel,Dahse, Hans-Martin,Weigel, Christiane,Lackner, Gerald,Beemelmanns, Christine
, p. 2307 - 2311 (2018)
Cyclic peptides containing non-proteinogenic amino acids often exhibit a broad bioactivity spectrum and many have entered clinical trials with good prospects for drug development. We recently reported the discovery of six cyclic tetrapeptides, pseudoxylallemycins A–F (1–6), from a termite-associated Pseudoxylaria sp. X802. These compounds contain a rare O-homoallenyl-l-tyrosine moiety and show promising antimicrobial activity against the Gram-negative pathogenic bacterium Pseudomonas aeruginosa. To perform more detailed structure–activity studies, we pursued a precursor-directed diversification strategy. Herein, we report the purification, identification, and testing of 21 new pseudoxylallemycin derivatives.
Synthesis and Bioactivity of Analogs of Maculosin, a Host-Specific Phytotoxin Produced by Alternaria alternaria on Spotted Knapweed (Centaurea maculosa)
Bobylev, Mikhail M.,Bobyleva, Ludmila I.,Strobel, Gary A.
, p. 3960 - 3964 (2007/10/03)
Maculosin (cyclo-Pro-Tyr), a host-specific phytotoxin produced by Alternaria alternata on spotted knapweed (Centaurea maculosa), is an ideal prototype for creating a safe and an environmentally friendly antiknapweed herbicide. To evaluate this possibility