120129-83-1Relevant articles and documents
Syntheses and antitumor evaluation of C(6)-isobutyl- and C(6)-isobutenyl-substituted pyrimidines, and dihydropyrrolo[1,2-c]pyrimidine-1, 3-diones
Kristafor, Svjetlana,Kraljevic, Tatjana Gazivoda,Ametamey, Simon M.,Cetina, Mario,Ratkaj, Ivana,Hacek, Romana Tandara,Pavelic, Sandra Kraljevic,Raic-Malic, Silvana
experimental part, p. 1455 - 1469 (2011/11/05)
A growing body of evidence supports that pyrimidine derivatives, in which the sugar residues have been replaced by acyclic side chains, might be developed as promising anticancer agents that interfere with tumor cell proliferation, survival, and metastati
Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: New lead structures for monitoring gene expression in vivo
Martic, Miljen,Pernot, Lucile,Westermaier, Yvonne,Perozzo, Remo,Kraljevic, Tatjana Gazivoda,Kristafor, Svjetlana,Raic-Malic, Silvana,Scapozza, Leonardo,Ametamey, Simon
, p. 293 - 315 (2012/02/03)
Novel C-6 substituted pyrimidine derivatives are good substrates of herpes simplex virus type 1 thymidine kinase (HSV1-TK). Enzyme kinetic experiments showed that our lead compound, N-methyl DHBT (N-methyl-6-(1,3-dihydroxyisobutyl) thymine; N-Me DHBT), is
Methoxymethyl (MOM) group nitrogen protection of pyrimidines bearing C-6 acyclic side-chains
Kraljevic, Tatjana Gazivoda,Petrovic, Martina,Kristafor, Svjetlana,Makuc, Damjan,Plavec, Janez,Ross, Tobias L.,Ametamey, Simon M.,Raic-Malic, Silvana
, p. 5113 - 5129 (2011/08/06)
Novel N-methoxymethylated (MOM) pyrimidine (4-13) and pyrimidine-2,4- diones (15-17) nucleoside mimetics in which an isobutyl side-chain is attached at the C-6 position of the pyrimidine moiety were synthesized. Synthetic methods via O-persilylated or N-a
Synthesis, 18F-radiolabelling and biological evaluations of C-6 alkylated pyrimidine nucleoside analogues
Raic-Malic, Silvana,Johayem, Anass,Ametamey, Simon M.,Batinac, Sanja,De Clercq, Erik,Folkers, Gerd,Scapozza, Leonardo
, p. 1707 - 1721 (2007/10/03)
Synthesis of pyrimidine derivatives with a side-chain attached to the C-6 of pyrimidine ring (6-14) is reported. Target compounds 8 and 12 were subjected to in vitro phosphorylation tests, determination of their binding affinities to herpes simplex virus