85678-97-3

Upstream product

• 153683-83-1 4,4-dimethyl-2-<1-(phenylsulfinyl)naphthalen-2-yl>-4,5-dihydrooxazole 
• 51439-63-5 1-methoxy-2-naphthoyl chloride 
• 883-21-6 1-methoxy-2-naphthoic acid 
• 117052-90-1 Naphthalene-2-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide 
• 109660-11-9 4,4-dimethyl-2-(naphthalen-2-yl)-4,5-dihydrooxazole 
• 162920-48-1 4,4-dimethyl-2-<1-(phenylsulfanyl)naphthalen-2-yl>-4,5-dihydrooxazole 
• 93530-92-8 2-<2-(1-bromonaphthyl)>-4,4-dimethyl-Δ²-oxazoline 
• 100-58-3 phenylmagnesium bromide 
• 117053-23-3 1-phenyl-2-(4,4-dimethyl-2-oxazolinyl)-1,4-dihydronaphthalene 
• 78265-10-8 2-<2-(1-methoxynaphthyl)>-4,4-dimethyl-Δ²-oxazoline 

Downstream Products

• 85679-03-4 1-phenylnaphthalene-2-carboxylic acid 

Relevant academic research and scientific papers

Atropisomer-selective ligand-coupling reactions of sulfoxides. X-Ray molecular and crystal structures for 2-(thiophen-3-yl>amino)-2-methylpropan-1-ol, 2-(2-hydroxy-1,1-dimethylethyl)-2,3-dihydronaphthoisothiazol-3-one and (R)-(+)-2-bromo-1-(tert...

1-(Alkyl- or aryl-sulfinyl)naphthalenes activated by electron-withdrawing substituents at the 2-position undergo substitution reactions on treatment with Grignard reagents.Evidence suggesting that these transformations proceed through ligand-coupling reactions of ?-sulfuranes is presented.The ligand-coupling reaction of homochiral sulfoxides with 1-naphthylmagnesium bromide furnishes atropisomeric 1,1'-binaphthyls in 60-95percent ee.Single-crystal X-ray structure determinations have been carried out on 2-(thiophen-3-yl>amino)-2-methylpropan-1-ol 18 and 2-(2-hydroxy-1,1-dimethylethyl)-2,3-dihydronaphthoisothiazol-3-one 22, compounds formed through intramolecular nucleophilic and electrophilic attack, respectively, on a neighbouring oxazoline group.The absolute configuration of (R)-(+)-1-(tert-butylsulfinyl)naphthalene 27 was determined by a single-crystal X-ray study of the 2-bromo-derivative 28.

Atropisomer-selective 1,1-Binaphthyl Synthesis via Chirality Transfer from Sulfur

4,5-Dihydro-2-(1-alkyl- or 1-aryl-sulfinylnaphthalen-2-yl)-4,4-dimethyloxazoles 3-6 undergo substitution reactions on treatment with Grignard reagents; the optically active sulfoxide 14 on treatment with 1-naphthylmagnesium bromide furnished the 1,1-binap

REGIO-AND STEREOSELECTIVE ADDITION OF ORGANOLITHIUMS TO NAPHTHALENES. AN EFFICIENT SYNTHESIS OF 1,1,2-TRISUBSTITUTED AND TRANS-2-DISUBSTITUTED DIHYDRONAPHTHALENES

The addition of a variety of organolithium reagents to 1-naphthyloxazolines and 2-naphthyloxazolines followed by trapping with electrophiles leads to high yields of the title compounds.Very high stereoselectivity characterizes the present process in that