856782-36-0Relevant academic research and scientific papers
Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity
Thompson, Mark J.,Louth, Jennifer C.,Ferrara, Steven,Jackson, Matthew P.,Sorrell, Fiona J.,Cochrane, Edward J.,Gever, Joel,Baxendale, Sarah,Silber, B. Michael,Roehl, Henry H.,Chen, Beining
experimental part, p. 4125 - 4132 (2011/11/12)
A series of highly potent indole-3-glyoxylamide based antiprion agents was previously characterized, focusing on optimization of structure-activity relationship (SAR) at positions 1-3 of the indole system. New libraries interrogating the SAR at indole C-4
